Results 51 to 60 of about 12,316 (251)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Reading speed, visual deficits, and cerebral white matter integrity in veterans with and without mild traumatic brain injury

Frontiers in Neuroscience
IntroductionSince 2001, approximately 17.3% of enlisted personnel have experienced a traumatic brain injury (TBI) according to the United States military. Visual deficits (e.g., convergence insufficiency or pursuit abnormalities) are reported as chronic,
Kori E. Skrypek, Kori E. Skrypek, Philip C. Burton, Nicholas D. Davenport, Scott R. Sponheim, Scott R. Sponheim, Cheryl A. Olman   +6 more
doaj   +1 more source

Changes in the disparity vergence main sequence after treatment of symptomatic convergence insufficiency in children

Journal of Eye Movement Research, 2019
This study investigates the underlying physiological mechanisms that may lead to improved outcomes for symptomatic convergence insufficiency (CI) patients after 12 weeks of office-based vergence/accommodation therapy (OBVAT) by evaluating the change in ...
Mitchell Scheiman, Chang Yaramothu, Tara L. Alvarez   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university students [PDF]

International Journal of Ophthalmology
AIM: To investigate the frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university students.
Jie Cai, Wen-Wen Fan, Yun-Hui Zhong, Cai-Lan Wen, Xiao-Dan Wei, Wan-Chen Wei, Wan-Yan Xiang, Jin-Mao Chen   +7 more
doaj   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

A Pilot Study of Disparity Vergence and Near Dissociated Phoria in Convergence Insufficiency Patients Before versus After Vergence Therapy

Frontiers in Human Neuroscience, 2015
PURPOSE: This study examined the relationship between the near dissociated phoria and disparity vergence eye movements. Convergence insufficiency (CI) patients before vergence therapy were compared to: 1) the same patients after vergence therapy and 2 ...
Tara L. Alvarez
doaj   +1 more source

Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park, Eun‐Hyuk Choi, Jorge Otero‐Millan, David S. Zee, Jeong‐Yoon Choi, Ji‐Soo Kim   +5 more
wiley   +1 more source

Factor structure of the convergence insufficiency symptom survey questionnaire.

PLoS ONE, 2020
The purpose of this study is to analyze the factorial structure of the Convergence Insufficiency Symptom Survey questionnaire with 15 items, in order to identify latent dimensions that can contribute to a more focused implementation.
Amélia Fernandes Nunes, Pedro Lourenço Monteiro, António Santos Nunes   +2 more
doaj   +1 more source