Results 61 to 70 of about 749,022 (282)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Case Report Convergence Insufficiency/Divergence Insufficiency Convergence Excess/Divergence Excess: Some Facts and Fictions [PDF]

, 2020
Great discrepancies are often encountered between the distance fixation and the near-fixation esodeviations and exodeviations. They are all attributed to either anomalies of the AC/A ratio or anomalies of the fusional convergence or divergence amplitudes.
Alaa Boughannam, Ramzi Alameddine, Edward Khawam, Bachir Abiad, Joanna Saade   +4 more
core  

Factors Influencing the Surgical Success in Patients with Infantile Esotropia

Türk Oftalmoloji Dergisi, 2013
Purpose: To determine the factors that influence the surgical success in patients with infantile esotropia and to evaluate the relationship between amount of bilateral medial rectus recession and convergence.
Fatma Gül Yılmaz Çınar, Deniz Somer, Ayşe Burcu, Züleyha Yalnız Akkaya, Firdevs Örnek   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Are near visual signs and symptoms in multiple sclerosis compatible with convergence insufficiency?

, 2021
Clinical relevance: Optometric management of neurodegenerative diseases is essential since visual signs, such as double vision, visual acuity reduction, or oculomotricity dysfunctions, are usually present in these subjects over the course of the disease.
Gil-Casas, Amparo, Piñero, David P., Molina-Martín, Ainhoa   +2 more
core   +1 more source

Functional activity within the frontal eye fields, posterior parietal cortex and cerebellar vermis significantly correlates to symmetrical vergence peak velocity: An ROI-based, fMRI study of vergence training

Frontiers in Integrative Neuroscience, 2014
Convergence insufficiency (CI) is a prevalent binocular vision disorder with symptoms that include double/blurred vision, eyestrain, and headaches when engaged in reading or other near work.
Tara L Alvarez, Raj eJaswal, Suril eGohel, Bharat B Biswal   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Convergence Insufficiency Neuro-mechanism in Adult Population Study Randomized Clinical Trial: Clinical Outcome Results

, 2020
SIGNIFICANCE These data confirm the effectiveness of office-based vergence/accommodative therapy for improving the near point of convergence and positive fusional vergence in young adults with symptomatic convergence insufficiency within a double-masked ...
John Vito d'Antonio-Bertagnolli, Yaramothu, Chang, Mitchell Scheiman, Tara L. Alvarez, Santos, Elio M., Elio M. Santos, D\u27Antonio-Bertagnolli, John Vito, Scheiman, Mitchell, Alvarez, Tara L., Chang Yaramothu   +9 more
core   +1 more source

Reading speed, visual deficits, and cerebral white matter integrity in veterans with and without mild traumatic brain injury

Frontiers in Neuroscience
IntroductionSince 2001, approximately 17.3% of enlisted personnel have experienced a traumatic brain injury (TBI) according to the United States military. Visual deficits (e.g., convergence insufficiency or pursuit abnormalities) are reported as chronic,
Kori E. Skrypek, Kori E. Skrypek, Philip C. Burton, Nicholas D. Davenport, Scott R. Sponheim, Scott R. Sponheim, Cheryl A. Olman   +6 more
doaj   +1 more source