Results 171 to 180 of about 166,235,716 (309)

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Enhanced Osprey Optimization Algorithm for Global Optimization with Application to PEM Fuel Cell Parameter Identification. [PDF]

Biomimetics (Basel)
Bouali Y, Alamri B.
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

ECONOMIC CONVERGENCE OF CZECH REGIONS IN TERMS OF GDP AND UNEMPLOYMENT RATE IN RESPONSE TO FDI FLOWS: DO BUSINESSES AND REGIONS FLOURISH?

, 2019
The convergence analysis of regions of the Czech Republic is performed in the period 2000-2017. Two convergence concepts are methodologically described and applied: 1) the regional variability of real gross domestic product per capita is examined by the ...
Veronika, Machová, Hašková, Simona, Volf, Petr   +2 more
core  

DSD-LI-PO: A Bioinspired Parrot Optimizer with Componentwise Swarm Hybridization and Contracted Lens Imaging Refinement for Constrained Engineering Optimization. [PDF]

Biomimetics (Basel)
Qin M, Ding Y.
europepmc   +1 more source

Posterior Disconnection Syndrome in Early‐Stage Adult‐Onset Cerebral Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual
Kazuto Katsuse, Takashi Matsukawa, Yumiko Nakamura, Kazuo Kakinuma, Shoko Ota, Ryo Hara, Saki Nakashima, Kaoru Ito, Yutaro Nakamori, Toshiyuki Kakumoto, Masashi Hamada, Shigenori Kanno, Kyoko Suzuki, Tatsushi Toda   +13 more
wiley   +1 more source

A three-term conjugate gradient method with a new descent structure for unconstrained optimization and low-carbon supply chain optimization. [PDF]

PLoS One
Malik M, Ibrahim SM, Lestari D, Novkaniza F, Devila S, Addini FF, Gunawan G.   +6 more
europepmc   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Convergence and divergence in media: different perspectives

, 2004
A current issue in the media industry is coping with the effects of convergence. The concept of convergence is frequently used both in the academic field and within the media industry to denote the ongoing restructuring of media companies as well as to ...
E. Appelgren
core  

Hyperspectral Image Classification Based on an Improved Octopus Optimization Algorithm. [PDF]

Biomimetics (Basel)
Xu Y, Jiang L, Zhang Y.
europepmc   +1 more source