Results 121 to 130 of about 14,949,583 (325)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Geometric Approximation of Point Interactions in Three-Dimensional Domains

Mathematics
In this paper, we study a three-dimensional second-order elliptic operator with a point interaction in an arbitrary domain. The operator is supposed to be self-adjoint.
Denis Ivanovich Borisov
doaj   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Convergence Rates for Logspline Tomography

Journal of Multivariate Analysis, 1998
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

A Double-Parameter Regularization Scheme for the Backward Diffusion Problem with a Time-Fractional Derivative

Fractal and Fractional
In this paper, we investigate the regularization of the backward problem for a diffusion process with a time-fractional derivative. We propose a novel double-parameter regularization scheme that integrates the quasi-reversibility method for the governing
Qun Chen, Zewen Wang
doaj   +1 more source

The inverse moment for widely orthant dependent random variables

Journal of Inequalities and Applications, 2016
In this paper, we investigate approximations of the inverse moment model by widely orthant dependent (WOD) random variables. Let { Z n , n ≥ 1 } $\{Z_{n},n\geq1\}$ be a sequence of nonnegative WOD random variables, and { w n i , 1 ≤ i ≤ n , n ≥ 1 } $\{w_{
Xiaoqin Li, Xi Liu, Wenzhi Yang, Shuhe Hu   +3 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

A finite element method for exterior interface problems

International Journal of Mathematics and Mathematical Sciences, 1980
A procedure is given for the approximate solution of a class of two-dimensional diffraction problems. Here the usual inner boundary conditions are replaced by an inner region together with interface conditions.
R. C. Maccamy, S. P. Marin
doaj   +1 more source