Results 41 to 50 of about 6,006,594 (257)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Convergence Analysis on Multi-AUV Systems With Leader-Follower Architecture

IEEE Access, 2017
In multi-autonomous underwater vehicle (multi-AUV) systems, the convergence rate is characterized by the pace of consistency of the key state information for each member.
Wen Xing, Yuxin Zhao, Hamid Reza Karimi
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Asymptotics of the Joint Distribution of Multivariate Extrema

Nonlinear Analysis, 2001
Let Wn and Zn be a bivariate extrema of independent identically distributed bivariate random variables with a distribution function F. in this paper the nonuniform estimate of convergence rate of the joint distribution of the normalized and centralized ...
A. Aksomaitis, A. Jokimaitis
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

On the O ( 1 / t ) $O(1/t)$ convergence rate of the alternating direction method with LQP regularization for solving structured variational inequality problems

Journal of Inequalities and Applications, 2016
In this paper, we propose a parallel descent LQP alternating direction method for solving structured variational inequality with three separable operators. The O ( 1 / t ) $O(1/t)$ convergence rate for this method is studied.
Abdellah Bnouhachem, Abdul Latif, Qamrul Hasan Ansari   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Convergence and Almost Sure Polynomial Stability of Partially Truncated Split-Step Theta Method for Stochastic Pantograph Models with Lévy Jumps

Mathematics
This paper addresses a stochastic pantograph model with Lévy leaps where non-jump coefficients exceed linearity. The partially truncated split-step theta method is introduced and applied to the proposed model.
Amr Abosenna, Ghada AlNemer, Boping Tian
doaj   +1 more source

State augmentation-based modified iterated extended Kalman filtering

Dianzi Jishu Yingyong, 2020
This paper derives a state augmentation-based modified iterated extended Kalman filter(SMIEKF) by making use of the state augmentation technique, in which the state variables are directly augmented with the measurement noise.
Liu Meihong, Gao Shanfeng, Li Wei, Xie Bin   +3 more
doaj   +1 more source