Results 51 to 60 of about 3,698,697 (306)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Convergence rates in homogenization of p-Laplace equations

Boundary Value Problems, 2019
This paper is concerned with homogenization of p-Laplace equations with rapidly oscillating periodic coefficients. The main difficulty of this work is due to the nonlinear structure in this field concerning p-Laplace equations itself. Utilizing the layer
Jie Zhao, Juan Wang
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nonlinear Stochastic Convergence Analysis of Regional Unemployment Rates in Poland [PDF]

This paper analyses convergence of unemployment rates in Poland at NUTS4 level by testing nonlinear convergence, applying the modified KSS-CHLL for each pair of territorial units. The results suggest that actually the convergence is a rare phenomenon and
Piotr Wójcik, Joanna Tyrowicz
core   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Convergence rates of nonlinear Stokes problems in homogenization

Boundary Value Problems, 2019
In this paper, we study the convergence rates of solutions in homogenization of nonlinear Stokes Dirichlet problems. The main difficulty of this work is twofold.
Juan Wang, Jie Zhao
doaj   +1 more source

European and global financial integration: some panel evidence of the convergence of interest rates [PDF]

Banks and Bank Systems, 2016
This paper seeks to contribute to the literature on financial integration using panel estimates to test beta- and sigma-convergence across the European Union countries’ interest rates and towards two specific benchmarks — the German and US rates ...
Cândida Ferreira
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Pairwise Learning With Gaussian Empirical Gain Function

IEEE Access
This article investigate the performance of Gaussian Empirical Gain Maximization (EGM) in a regression setting and conduct a detailed theoretical analysis, particularly in the presence of heavy-tailed noise, where this article establish improved ...
Gongli Chen, Qian Sun, Shouyou Huang
doaj   +1 more source