Results 51 to 60 of about 219,279 (313)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

EDUCATIONAL PERFORMANCE AND SPATIAL CONVERGENCE IN PERU [PDF]

open access: yes
While an enormous and growing literature exists on the topic of re-gional income convergence, other aspects of socioeconomic well-being and development have attracted much less attention. Social indicators are a valuable complement to economic indicators
Sergio J. REY, Maribel ELIAS
core   +2 more sources

A Review on Mechanical Proving and Formalization of Mathematical Theorems

open access: yesIEEE Access
The field of artificial intelligence represents a frontier and a focal point of contemporary technological development. As an important embodiment of artificial intelligence applied to theoretical-level research, mechanical proving has been a subject of ...
Si Chen   +3 more
doaj   +1 more source

Three-Step Derivative-Free Method of Order Six

open access: yesFoundations, 2023
Derivative-free iterative methods are useful to approximate the numerical solutions when the given function lacks explicit derivative information or when the derivatives are too expensive to compute.
Sunil Kumar   +3 more
doaj   +1 more source

Mereology on Topological and Convergence Spaces

open access: yesNotre Dame Journal of Formal Logic, 2013
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

SPATIAL AND SECTORAL PRODUCTIVITY CONVERGENCE BETWEEN EUROPEAN REGIONS, 1975-2000 [PDF]

open access: yes
This paper analyzes the evolution of labor productivity disparities among 145 European regions over 1975-2000 according to the concepts of sigma- and beta-convergence and emphasizes the importance of including both spatial effects and a disaggregated ...
Julie Le Gallo, Sandy Dall’erba
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Large-Dynamic-Range Dual-Parameter Sensor Using Broad FSR Multimode Photonic Crystal Nanobeam Cavity

open access: yesIEEE Photonics Journal, 2018
We theoretically propose an ultracompact large-dynamic-range dual-parameter sensor using a broad free spectral range (FSR) multimode photonic crystal nanobeam cavity (MM-PCNC).
Chao Wang   +4 more
doaj   +1 more source

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