Results 101 to 110 of about 572,188 (337)

Gestural Ways of Depicting Metaphors and Abstract Concepts

Studies in Logic, Grammar and Rhetoric
The aim of the article is to present ways in which gestures combine with the verbal layer of an utterance, thus reflecting embodied thinking and the rooting of abstract concepts in human bodily experience.
Kraśnicka Izabela
doaj   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Conversation

Littera Scripta, 2011
This brief contribution offers a review of a book called Conversation published in a line of Resource books for teachers by OUP. The authors and the series editor Alan Maley have been all involved with English for some time. Either they have been teaching
Jindřiška Šulistová
doaj  

Talking on a Wireless Cellular Device While Driving: Improving the Validity of Crash Odds Ratio Estimates in the SHRP 2 Naturalistic Driving Study

Safety, 2017
Dingus and colleagues (Proc. Nat. Acad. Sci. U.S.A. 2016, 113, 2636–2641) reported a crash odds ratio (OR) estimate of 2.2 with a 95% confidence interval (CI) from 1.6 to 3.1 for hand-held cell phone conversation (hereafter, “Talk”) in the SHRP 2 ...
Richard A. Young
doaj   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Trouver l'organisation dans la communication : Le discours comme action et signification

Communiquer
Cet article discute de deux façons dont le langage et le discours sont associés dans la conception de l'organisation : en tant qu'activités communicationnelles des agent·e·s (conversations); et en tant qu'interprétations discursives définissant les agent·
James R. Taylor, Daniel Robichaud
doaj   +1 more source

Menaces of Liberal Education: M. Oakeshott [PDF]

Meta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2012
In the present text I discuss Michael Oakeshott’s idea of liberal education and its main menace, authority. By identifying two ways of examining the issue of authority, I launch two different perspectives on this issue.
Dana Tabrea
doaj  

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source