Results 81 to 90 of about 510,300 (249)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Coffee and Conversation 2011 [PDF]

open access: yes, 2011
The weekly HTC programming of Coffee and Conversation hosted by Dean ...
Boston University Howard Thurman Center for Common Ground
core   +1 more source

Faut-il institutionnaliser l’ECTQG?

open access: yes, 2017
Le 20e Colloque Européen de Géographie Théorique et Quantitative s’est tenu à York, du 7 au 11 septembre 2017. Organisé par nos collègues de l’université de Leeds, Michelle Morris, Mark Birkin et Nick Malleson, il a réuni environ 80 participants issus de
Cybergeo Conversation
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Gaze alternation predicts inclusive next-speaker selection: evidence from eyetracking

open access: yesFrontiers in Communication
Next-speaker selection refers to the practices conversationalists rely on to designate who should speak next. Speakers have various methods available to them to select a next speaker.
Christoph Rühlemann
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Aspectos contextuales en la formación de diseñadores: comprender el taller de diseño = Contextual aspects in the training of designers: understanding the design-studio

open access: yesArte, Diseño e Ingeniería, 2017
Resumen El taller de diseño ha sido abordado por distintos autores los cuales se expondrán a través de este texto, destacando algunas particularidades que van desde cómo un espacio contextual como el mismo, impacta en la forma en que un estudiante ...
Ricardo López León
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Gestural Ways of Depicting Metaphors and Abstract Concepts

open access: yesStudies in Logic, Grammar and Rhetoric
The aim of the article is to present ways in which gestures combine with the verbal layer of an utterance, thus reflecting embodied thinking and the rooting of abstract concepts in human bodily experience.
Kraśnicka Izabela
doaj   +1 more source

The relationship between internal and external conversation [PDF]

open access: yes
This study offers a definition, description, analytical theorisation and critical discussion concerning the relationship between internal and external conversation.
Chalari, Athanasia
core  

Home - About - Disclaimer - Privacy