Results 111 to 120 of about 650,823 (326)

A Family Approach to Philanthropy and a Lasting Family Foundation [PDF]

, 2015
This white paper reveals the output of a Family Office Council roundtable held in 2015, which was facilitated by CAF, in which philanthropy management issues faced by Family Offices and families were explored. The discussion focused on how Family Offices

core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Examination of Communication Skills in Children with Cochlear Implants and Hearing Children

Ankara Üniversitesi Eğitim Bilimleri Fakültesi Özel Eğitim Dergisi
Introduction: This study aims to compare the communication skills of children with hearing loss who use cochlear implants with those of children with normal hearing and to identify the variables associated with the communication skills of cochlear ...
Esra Genç, Yıldız Uzuner
doaj   +1 more source

Refugees, Food Insecurity, and Community Gardens [PDF]

, 2011
Nearly nine in ten resettled refugee households endure food insecurity, meaning that they are without “access to sufficient, safe, nutritious food to maintain a healthy and active life.” Because western New York resettles hundreds of refugees per year ...
Rolston, Dorian
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Raising Aid Efficiency with International Development Aid Monitoring and Evaluation Systems

Journal of MultiDisciplinary Evaluation, 2019
Background: Since the adoption of the Millennium Development Goals (MDGs), or more specifically perhaps the Monterrey Consensus, there has been a distinct shift in the conversation around assessing the development effectiveness of international aid ...
Hans Martin Boehmer, Yury K. Zaytsev
doaj   +1 more source

Evaluation of the Conversations about Non-Suicidal Self-Injury Mental Health First Aid Course: Effects on Knowledge, Stigmatising Attitudes, Confidence and Helping Behaviour [PDF]

, 2023
Kathy S. Bond, Julia Lyons, Fairlie A. Cottrill, Amanda Sabo, Simone E. Baillie, Alyssia Rossetto, Louise Kelly, Claire M. Kelly, Nicola Reavley, Anthony F. Jorm, Amy J. Morgan   +10 more
openalex   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source