Results 91 to 100 of about 650,823 (326)

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Investigating conversational dynamics in triads: Effects of noise, hearing impairment, and hearing aids

open access: yesFrontiers in Psychology
Communication is an important part of everyday life and requires a rapid and coordinated interplay between interlocutors to ensure a successful conversation.
Eline Borch Petersen
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Trust in Conversation

open access: yesNordic Wittgenstein Review, 2014
We may think of the notion of “trust” primarily in epistemological terms or, alternatively, primarily in ethical terms. These different ways of thinking of trust are linked with different ways of picturing language, and my relation to the words of ...
David Cockburn
doaj  

Promoting College Match for Low-Income Students: Lessons for Practitioners [PDF]

open access: yes, 2013
Most high school reform efforts understandably focus on boosting the success of low-income students who are underachieving academically, but in every school district where students struggle, there are academically capable low-income and minority students
Chera Reid, D. Crystal Byndloss
core  

Innovation in Mobile Learning: A European Perspective [PDF]

open access: yes, 2009
In the evolving landscape of mobile learning, European researchers have conducted significant mobile learning projects, representing a distinct perspective on mobile learning research and development.
Arnedillo-Sánchez, Inmaculada   +4 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Do Not Send Us So We Can Become Refugees Again' From 'nationals of a hostile state' to deportees: South Sudanese in Israel [PDF]

open access: yes, 2013
The focus of this report is the collective non-removal policy towards asylum seekers in Israel. This policy, the terms of which have never been clearly defined by the Israeli authorities, applies to most of the 55,000 African asylum seekers in the ...
Laurie Lihnders
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

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