Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The Costs of Implementing a Conversation Aid for Uterine Fibroids in Multiple Health Care Settings. [PDF]
Med Care, 2023 Acquilano SC +7 more
europepmc +1 more source
Radical Housing JournalThis conversation examines the Movimiento de Ocupantes e Inquilinos (MOI) in Argentina, a grassroots organization promoting cooperative, self-managed housing for over 30 years.
Néstor Jeifetz +2 more
doaj +1 more source
IMPROVING STUDENTS’ SPEAKING ABILITY BY USING INSTRUCTIONAL MEDIA FOR ADVANCED LEARNERS
Lingua Didaktika: Jurnal Bahasa dan Pembelajaran Bahasa, 2015 Nowadays, the use of media in language learning is very important. It will make the teaching and learning process be more attractive and effective. Instructional media is an aid which is able to help teacher in their teaching activity.
Fitrawati Fitrawati
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A way of integrating deaf, hearing- and speech-impaired people into modern communication society
Journal of Telecommunications and Information Technology, 2006 This article deals with the exclusion of deaf, hearing- and speech-impaired people from our modern communication society, as they are unable to use the phone. This situation leads to discrimination and disadvantages in their everyday lives. One solution
Marlene Hilzensauer
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Correction to: Making sense of diabetes medication decisions: a mixed methods cluster randomized trial using a conversation aid intervention. [PDF]
Endocrine, 2023 Kunneman M +25 more
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source