Results 81 to 90 of about 650,823 (326)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Continuous adaptation of conversation aids for uterine fibroids treatment options in a four-year multi-center implementation project

BMC Medical Informatics and Decision Making
Background Fibroids are non-cancerous uterine growths that can cause symptoms impacting quality of life. The breadth of treatment options allows for patient-centered preference.
Danielle Schubbe, Marie-Anne Durand, Rachel C. Forcino, Jaclyn Engel, Marisa Tomaino, Monica Adams-Foster, Carla Bacon, Carrie Cahill Mulligan, Sateria Venable, Tina Foster, Paul J. Barr, Raymond M. Anchan, Shannon Laughlin-Tommaso, Anne Lindholm, Maya Seshan, Rossella M. Gargiulo, Patricia Stephenson, Karen George, Mobolaji Ajao, Tessa Madden, Erika Banks, Antonio R. Gargiulo, James O’Malley, Maria van den Muijsenbergh, Johanna W. M. Aarts, Glyn Elwyn   +25 more
doaj   +1 more source

Laughter Classification Using Deep Rectifier Neural Networks with a Minimal Feature Subset

Archives of Acoustics, 2016
Laughter is one of the most important paralinguistic events, and it has specific roles in human conversation. The automatic detection of laughter occurrences in human speech can aid automatic speech recognition systems as well as some paralinguistic ...
Gábor GOSZTOLYA, András BEKE, Tilda NEUBERGER, László TÓTH   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The UPFRONT project: tailored implementation and evaluation of a patient decision aid to support shared decision-making about management of symptomatic uterine fibroids

Implementation Science
Objective To evaluate implementation of a patient decision aid for symptomatic uterine fibroid management to improve shared decision-making at five clinical settings across the United States.
Rachel C. Forcino, Marie-Anne Durand, Danielle Schubbe, Jaclyn Engel, Erika Banks, Shannon K. Laughlin-Tommaso, Tina Foster, Tessa Madden, Raymond M. Anchan, Mary Politi, Anne Lindholm, Rossella M. Gargiulo, Maya Seshan, Marisa Tomaino, Jingyi Zhang, Stephanie C. Acquilano, Sade Akinfe, Anupam Sharma, Johanna W. M. Aarts, Glyn Elwyn   +19 more
doaj   +1 more source

Cooperativism as pedagogy: Conversation with Gustavo Machado a lecturer and researcher from Facultad de Ciencias Sociales de la Universidad de la República

Radical Housing Journal
This conversation with Gustavo Machado discusses the role of cooperativism as a pedagogical process in Uruguay. Machado emphasizes how cooperatives serve as models for housing production and transformative social learning processes, embedding ...
Gustavo Machado, Ana Vilenica, Moisés Quiroz   +2 more
doaj   +1 more source

Improved status following behavioural intervention in a case of severe dysarthria with stroke aetiology [PDF]

, 2012
There is little published intervention outcome literature concerning dysarthria acquired from stroke. Single case studies have the potential to provide more detailed specification and interpretation than is generally possible with larger participant ...
Lowit, Anja, Mackenzie, Catherine
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Negotiating the Politics of Race through Moral Cross-Cultural Conversation [PDF]

, 2001
Discussions about race/ethnicity are an important aspect of diversity on college campuses. This paper explores the social construct of race in the United States and the various barriers that arise when individuals engage in dialogue about this issue.
Diaz, Jacob L.
core   +1 more source

Shared decision making with frail people with intellectual disabilities in the palliative phase: A process evaluation of the use of the In‐Dialogue conversation aid in practice [PDF]

, 2023
Hanna W. Noorlandt, Ida J. Korfage, Freek M. A. J. Felet, K. Aarts, Dederieke A. M. Festen, Cis Vrijmoeth, Agnes van der Heide, Michael A. Echteld   +7 more
openalex   +1 more source