Results 51 to 60 of about 1,361,747 (244)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
¿Es cierta la conversión de san Hilario de Poitiers?
Estudios Eclesiásticos, 1967 La presente nota trata de dar una respuesta argumentada y analizada acerca de la veracidad sobre la conversión de san Hilario de Poitiers ante la falta de fuentes acerca de ello.
Antonio Peñamaría de Llano
doaj
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
El debate por los esclavos en las asambleas cristianas a fines del siglo II
Circe de Clásicos y Modernos, 2018 El objetivo de este trabajo es presentar la percepción cristiana de la esclavitud en la segunda mitad del siglo II desde el debate instaurado entre apologistas cristianos y escritores paganos sobre el rol de los esclavos en la extensión del culto ...
Mariano Spléndido
doaj
Nuevos datos y consideraciones sobre los orígenes y genealogía de los Banū Rušd
Al-Qantara : Revista de Estudios Arabes, 2018 Este artículo retoma la cuestión de los orígenes genealógicos del jurista mālikí y teólogo aš‘arí Ibn Rušd al-Ŷadd (m. 520/1126) —al que no hay que confundir con su famoso nieto, Ibn Rušd al-Ḥafīd o Averroes (m. 595/1198). Se aportan nuevas evidencias en
Delfina Serrano Ruano
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Isegoría, 2012 Un problema sociopolítico candente es el grado de representatividad pública que merezcan las religiones. Esta nota despliega el «estado de la cuestión» vertebrándolo en actitud crítica hacia el argumento básico común a los distintos interlocutores: la ...
Mercè Rius
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source