Results 81 to 90 of about 1,295,542 (267)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Influence of recycled flow operation on the value of minimum energy consumption

Тонкие химические технологии, 2011
The influence of recycled flow operation on the value of minimum energy consumption for total conversion of A reagent to B product was studied with A↔B reaction as an example.
S. L. Nazanskiy, A. V. Solokhin, O. Yu. Istomina   +2 more
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Use of side products recycling for increasing selectivity of complex reversible chemical reactions

Тонкие химические технологии, 2010
By the example of reversible parallel and consecutive reactions the possibility of using reagents and side products recycling in order to obtain high conversion and selectivity values was investigate.
A. V. Solokhin, S. L. Nazanskiy, T. V. Milyaeva   +2 more
doaj  

Conversion study of hepatocellular carcinoma using HAIC combined with lenvatinib and PD-1/L1 immunotherapy under the guidance of BCLC staging

Frontiers in Immunology
ObjectiveThis study aimed to assess the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) combined with lenvatinib and immunotherapy and explore its potential as a conversion treatment for unresectable hepatocellular carcinoma (uHCC ...
Weihao Zhang, Weihao Zhang, Weihao Zhang, Xiaohui Zhao, Xiaohui Zhao, Xiaohui Zhao, Wei Gao, Wei Gao, Wei Gao, Tongguo Si, Tongguo Si, Tongguo Si, Qiang Zou, Qiang Zou, Qiang Zou, Xueling Yang, Xueling Yang, Xueling Yang, Wenge Xing, Wenge Xing, Wenge Xing, Haipeng Yu, Haipeng Yu, Haipeng Yu   +23 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Decency, Humility, and Obedience: Spatial Discipline in the Baptist Rehab Centre

Journal of Ethnology and Folkloristics, 2016
This paper scrutinises the role of place and space in the process of Christian rehabilitation. This process is an interconnection of the rehabilitation of the addicted people and conversion to a particular kind of Christianity, working as an inseparable ...
Igor Mikeshin
doaj  

Conversions to Shiʿism in Italy and Editorial Ventures

Entangled Religions - Interdisciplinary Journal for the Study of Religious Contact and Transfer
This article presents an in-depth analysis of two interrelated topics, namely Italians’ conversions to Shiʿism and their contribution to disseminating knowledge about Twelver Shiʿism in Italy.
Minoo Mirshahvalad
doaj   +1 more source