Results 141 to 150 of about 1,482,675 (252)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Spin chemistry: the key to revolutionizing energy storage and conversion efficiency. [PDF]

Chem Sci
Zhang X, Pan J, Wan Y, Zheng X, Liu Y, Zhang Y, Liu X, Wei Q, Wu J, Iamprasertkun P, Wang B, Wu M, Hu H.   +12 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Integrative analysis of rumen microbiota and host multi-organ interactions underlying feed conversion efficiency in Hu sheep. [PDF]

J Anim Sci Biotechnol
Jia X, Zhang Y, Tian B, Zhang G, Mao S, Qian W, Sun D, Liu J.   +7 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Electron-Mediator-Free Microfluidic Photocatalytic Coenzyme Regeneration with 100% Conversion Efficiency within 126 S. [PDF]

Adv Sci (Weinh)
Chai Y, Wan L, Pang Z, Li X, Jia Z, Jiang H, Tsoi CC, Jia H, Shen J, Zhang Z, Long J, Xie F, Chen Y, Zhang X.   +13 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Engineered Substrate-Free Small Molecules for Enhanced Raman Scattering and Photothermal Conversion Efficiency. [PDF]

Adv Sci (Weinh)
Yu S, Gao S, Zhang Y, Zhang S, Sun J, Zhang W, Li T, Cui K, Xiao Z, Lu W.   +9 more
europepmc   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Tailoring Ba₃PCl₃-based perovskite solar cells via multi-parameter optimization for high power conversion efficiency. [PDF]

Sci Rep
Bhattarai S, Banthia R, Kumar A, Alali AS, Dwivedi DK, Tanti B, Maiti M, DasMahapatra S.   +7 more
europepmc   +1 more source