Results 121 to 130 of about 545,698 (316)
, 2013 This paper describes a multi-mode control strategy for the AC-DC converters used in small-scale wind turbine systems. The primary aim is to improve the performance of existing wind energy conversion systems.
Ertugrul, N. +5 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Technical limits for energy conversion efficiency
, 2019 To reach climate targets, unprecedented levels of energy efficiency improvements are required. To prioritise investments, it is necessary to know the energy saving potential associated with each action.
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Changes in Hospital Efficiency after Privatization [PDF]
We investigated the effects of privatization on hospital efficiency in Germany. To do so, we obtained bootstrapped DEA efficiency scores in the first stage of our analysis and subsequently employed a difference-in-difference matching approach within a ...
Oliver Tiemann, Jonas Schreyögg
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
System Design and Performance Analysis of a Distributed PV System
Kongzhi Yu Xinxi Jishu, 2014 It presents the design of electrical system and lightning protection system by taking an example of 117.6 kWp BAPV(building attached photovoltaic)project.
LI Jianquan +3 more
doaj
High Efficiency Thermoelectric Power Conversion
, 2005 Recent efforts at Teledyne Energy Systems, Inc. have lead to significant improvements in thermoelectric (TE) materials and power conversion devices. A number of improved formulations have been identified for standard n-type PbTe and p-type TAGS alloys ...
Donald F. Byrnes, Ben Heshmatpour
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