Results 71 to 80 of about 412,273 (267)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Performance enhancement of nanogenerator achieved in branch-heterostructure piezoelectric ceramic fiber toward electrical transmission power line monitoring

Journal of Advanced Ceramics
A flexible composite-based piezoelectric nanogenerator (PENG) with low cost, stable properties, and sensitivity to mechanical deformation is highly suitable for constructing self-powered sensing layers for distributed electrical transmission power lines.
Haowei Lu, Zhenghua Hu, Xin Wang, Gaoru Chen, Xiaogan Zheng, Jintao Xia, Mingju Huang, Wenlong Yang, Junhui Liu, Benlin Hu   +9 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Output Characteristics of GaAs Cell Irradiated by Laser

Photonic Sensors, 2018
The output characteristics of GaAs cell are keys for the laser wireless power transmission system design. The measurement platform for the output characteristics of GaAs cell is established by single-junction GaAs cell and 1064 nm fiber laser.
Xiaowei Li
doaj   +1 more source

Space-Efficient Conversions from SLPs

We give algorithms that, given a straight-line program (SLP) with $g$ rules that generates (only) a text $T [1..n]$, builds within $O(g)$ space the Lempel-Ziv (LZ) parse of $T$ (of $z$ phrases) in time $O(n\log^2 n)$ or in time $O(gz\log^2(n/z))$. We also show how to build a locally consistent grammar (LCG) of optimal size $g_{lc} = O(δ\log\frac{n}δ ...
Gagie, Travis, Goga, Adrián, Jeż, Artur, Navarro, Gonzalo   +3 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Reactivation of Decayed Positive Leader With Sudden Channel Elongation in Laboratory Long Spark

Geophysical Research Letters
Positive lightning leaders present reactivation behaviors during their propagation processes. The mechanism underlying the reactivation of positive leaders is yet unclear.
Dianhang Li, Weijiang Chen, Shengxin Huang, Bo Qi, Nianwen Xiang, Zhong Fu, Yufei Fu, Zimeng Zheng   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Artificial Mixed Fused Quartz Particles and Silicon Particles-Assisted High-Performance Multicrystalline Silicon

Crystals, 2019
Mixed seeds of fused quartz particles and silicon particles were laid at the bottom of the crucible to assist the growth of multicrystalline silicon crystals. The full melting process was used, and then we found that the grown crystals had higher quality.
Yanhuan Cai, Changcheng Mi, Xinming Huang   +2 more
doaj   +1 more source