Results 81 to 90 of about 14,613,539 (249)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Scientific and technical assistance to the evaluation of the safety of calcidiol monohydrate as a novel food

EFSA Journal
EFSA was asked by the European Commission to provide scientific assistance with respect to the EFSA adopted scientific opinion on ‘Safety of calcidiol monohydrate produced by chemical synthesis as a novel food pursuant to Regulation (EU) 2015/2283 ...
European Food Safety Authority (EFSA), Dominique Turck, Harry J. McArdle, Androniki Naska, Monika Neuhäuser‐Berthold, Giovanni Passeri, Ionut Craciun, Ruth Roldán‐Torres, Silvia Valtueña Martínez   +8 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

High-resolution transcriptional dissection of in vivo Atoh1-mediated hair cell conversion in mature cochleae identifies Isl1 as a co-reprogramming factor

PLoS Genetics, 2018
In vivo direct conversion of differentiated cells holds promise for regenerative medicine; however, improving the conversion efficiency and producing functional target cells remain challenging.
T. Yamashita, Fei Zheng, D. Finkelstein, Zoe Kellard, Robert A. Carter, Celeste D Rosencrance, Ken Sugino, J. Easton, Charles Gawad, J. Zuo   +9 more
semanticscholar   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Stacked volume conversion factor for geometric volume of Eucalyptus sp.

Agro@mbiente On-line, 2019
Post-harvest, wood volume can be calculated with a stacking factor which can be influenced by diameter classes involved. Consequently, the following question arises: there is a difference between the volume conversion factor for stacked to geometric ...
André Salgado de Andrade Sandim, Ariadna Coelho Mota, Mario Lima dos Santos, Welton dos Santos Barros, Beatriz Cordeiro Costa, Vanda Maria Sales de Andrade   +5 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Efficacy of Onabotulinum Toxin A (Botox) versus Abobotulinum Toxin A (Dysport) Using a Conversion Factor (1 : 2.5) in Treatment of Primary Palmar Hyperhidrosis

Dermatology research and practice, 2013
Background. Two preparations of botulinum A toxin (BTX-A) are commercially available for the treatment of palmar hyperhidrosis (PPH): Botox (Allergan; 100 U/vial) and Dysport (Ipsen Limited; 500 U/vial), which are not bioequivalent.
H. E. El Kahky, H. Diab, D. Aly, N. Farag   +3 more
semanticscholar   +1 more source

The linkage between phytoplankton productivity and photosynthetic electron transport in the summer from the Changjiang River to the East China Sea

Frontiers in Marine Science
Variable fluorescence measurements provide automatic and rapid estimates of electron-based photosynthesis. However, electron transport rates (ETR) to phytoplankton production vary greatly due to biological physiology and environmental stress along the ...
Shuyi Fei, Yonghui Gao, Yonghui Gao, Yonghui Gao, Ji Li, Ji Li, Ji Li, Lingzhi Cao   +7 more
doaj   +1 more source