Results 51 to 60 of about 112,175 (269)

On Restoration of the Blur Parameter in the Optical Sectioning Problem

open access: yesСовременные информационные технологии и IT-образование, 2022
The article considers the problem of finding the blur parameter between two images for the optical sectioning problem, in which the blur model has a natural optical origin associated with the use of incoherent white light as a radiation source in the ...
Sergey Bazhitov
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Rigorous Interpretation of Engineering Formulae for the Convolution and the Fourier Transform Based on the Generalized Integral

open access: yesIEEE Access, 2022
This paper aims at providing a framework suitable for justification of classical convolution integral and Fourier transform in many cases not covered by the usual definition of integral used for signal theory applications.
Zeljko Juric, Harun Siljak
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

ACNet: An Attention–Convolution Collaborative Semantic Segmentation Network on Sensor-Derived Datasets for Autonomous Driving

open access: yesSensors
In intelligent vehicular networks, the accuracy of semantic segmentation in road scenes is crucial for vehicle-mounted artificial intelligence to achieve environmental perception, decision support, and safety control.
Qiliang Zhang   +4 more
doaj   +1 more source

3D Convolution Conjugate Gradient Inversion of Potential Fields in Acoculco Geothermal Prospect, Mexico

open access: yesFrontiers in Earth Science, 2022
Potential field data have long been used in geophysical exploration for archeological, mineral, and reservoir targets. For all these targets, the increased search of highly detailed three-dimensional subsurface volumes has also promoted the recollection ...
José P. Calderón, Luis A. Gallardo
doaj   +1 more source

The convolution algebra

open access: yesAlgebra universalis, 2018
For a complete lattice $L$ and a relational structure $\mathfrak{X}=(X,(R_i)_I)$, we introduce the convolution algebra $L^{\mathfrak{X}}$. This algebra consists of the lattice $L^X$ equipped with an additional $n_i$-ary operation $f_i$ for each $n_i+1$-ary relation $R_i$ of $\mathfrak{X}$.
Harding, John   +2 more
openaire   +3 more sources

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

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