Results 51 to 60 of about 188,059 (287)
Convolutional Gated MLP: Combining Convolutions & gMLP
CoRR, 2021 Conference
A. Rajagopal, V. Nirmala
openaire +2 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Distribution of Distances between Elements in a Compact Set
Stats, 2019 In this article, we propose a review of studies evaluating the distribution of distances between elements of a random set independently and uniformly distributed over a region of space in a normed R -vector space (for example, point events generated
Solal Lellouche, Marc Souris
doaj +1 more source
Method of multilayer object sectioning based on a light scattering model
Компьютерная оптика, 2023 We discuss a problem of reconstructing (sectioning) multilayer object images in observed images obtained by focusing the imaging system on each layer and containing spurious blurry images of neighboring layers.
S.D. Bazhitov +3 more
doaj +1 more source
Convolutions in Overdrive: Maliciously Secure Convolutions for MPC
Proceedings on Privacy Enhancing Technologies, 2023 Machine learning (ML) has seen a strong rise in popularity in recent years and has become an essential tool for research and industrial applications. Given the large amount of high quality data needed and the often sensitive nature of ML data, privacy-preserving collaborative ML is of increasing importance.
Marc Rivinius +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
On Restoration of the Blur Parameter in the Optical Sectioning Problem
Современные информационные технологии и IT-образование, 2022 The article considers the problem of finding the blur parameter between two images for the optical sectioning problem, in which the blur model has a natural optical origin associated with the use of incoherent white light as a radiation source in the ...
Sergey Bazhitov
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source