Results 51 to 60 of about 52,742 (268)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Fast Gaussian Filter Approximations Comparison on SIMD Computing Platforms

open access: yesApplied Sciences
Gaussian filtering, being a convolution with a Gaussian kernel, is a widespread technique in image analysis and computer vision applications. It is the traditional approach for noise reduction.
Ekaterina O. Rybakova   +2 more
doaj   +1 more source

A Characterization of the Compound Multiparameter Hermite Gamma Distribution via Gauss’s Principle

open access: yesThe Scientific World Journal, 2013
We consider the class of those distributions that satisfy Gauss's principle (the maximum likelihood estimator of the mean is the sample mean) and have a parameter orthogonal to the mean.
Werner Hürlimann
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Randomly stopped maximum and maximum of sums with consistently varying distributions

open access: yes, 2017
Let $\{\xi_1,\xi_2,\ldots\}$ be a sequence of independent random variables, and $\eta$ be a counting random variable independent of this sequence. In addition, let $S_0:=0$ and $S_n:=\xi_1+\xi_2+\cdots+\xi_n$ for $n\geqslant1$. We consider conditions for
Andrulytė, Ieva Marija   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

On the connections between Fibonacci and Mulatu Numbers

open access: yesIntermaths
In this work, we present a detailed study of the Fibonacci--Mulatu sequence, {FMn}, defined recursively by FMn+2=FMn+1+FMn with initial terms FM0 = 4 and FM1 = 1.
Eudes Antonio Costa   +2 more
doaj   +1 more source

Euler Polynomials and Combinatoric Convolution Sums of Divisor Functions with Even Indices

open access: yesAbstract and Applied Analysis, 2014
We study combinatoric convolution sums of certain divisor functions involving even indices. We express them as a linear combination of divisor functions and Euler polynomials and obtain identities D2k(n)=(1/4)σ2k+1,0(n;2)-2·42kσ2k+1(n/4)  -(1/2)[∑d|n,d ...
Daeyeoul Kim   +2 more
doaj   +1 more source

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