Results 121 to 130 of about 88,078 (309)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Enfermedad de Creutzfeldt-Jakob en un paciente interpretado como encefalitis por herpes simple Creutzfeldt-Jakob disease in a patient with possible herpes simplex encephalitis

open access: yesRevista Cubana de Medicina, 2010
Se presentó un paciente con una enfermedad de Creutzfeldt-Jakob, al cual se le realizó un diagnóstico presuntivo inicial de encefalitis por herpes simple, que comenzó con trastornos conductuales, agresividad, alucinaciones visuales y pérdida progresiva ...
Edmundo Rivero Arias   +3 more
doaj  

Les convulsions 6 Au niveau des urgences pédiatriques -annees 2009- [PDF]

open access: yes, 2010
L'année 2009 a reconnu 158 cas de convulsions au niveau des urgences pédiatrique dont la majorité sont des convulsions racontées (97 cas). Le sexe masculin est légèrement plus touché avec un pic de fréquence entre 1 et 5 ans et le risque est plus ...
Leyou, Zineb, Mansouri, Yacoub
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Neonatal convulsions [Convulsiones neonatales] [PDF]

open access: yes, 2003
The incidence and physiopathology of neonatal convulsions, convulsive syndromes and neonatal status epilepticus were reviewed. Clinical and electroencephalographic manifestations will be discussed as well as laboratory and clinical diagnostic criteria ...
Sfaello, Zenón Milcíades
core   +1 more source

Genetics of Familial Infantile Convulsions

open access: yes, 1997
Four families from northwestern France with autosomal dominant benign infantile convulsions and paroxysmal choreoathetosis were studied genetically by linkage analysis at the Wellcome Trust Centre for Human Genetics, University of Oxford, UK, and at ...
J Gordon Millichap
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Anemia, inflammation, circadian rhythm and season effects in febrile convulsions

open access: yes
OBJECTIVE: Our aim in the study is to investigate circadian rhythm, season, age, gender, and hemogram parameters in children diagnosed with febrile convulsions.
Kara, Ilknur Surucu   +3 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

DEMOGRAPHIC AND CLINICAL CHARACTERISTICS OF CHILDREN WITH CEREBRAL PALSY RECEIVING INPATIENT TREATMENT

open access: yesПаёми Сино
Objective: To describe the clinical and demographic characteristics of children with CP who underwent inpatient treatment at the OICCH. Methods: A comparative analysis was conducted to examine the medical history and condition of 160 children ...
Abdykarova Ayperi Sadirdinovna   +4 more
doaj   +1 more source

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