Results 131 to 140 of about 88,078 (309)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ETHER CONVULSIONS [PDF]

BMJ, 1930
openaire   +2 more sources

Burst suppression EEG in neonatal convulsions

, 2010
Convulsions represent a characteristic signal of neurological disease in the newborn period. Single-channel EEG is a convenient tool for continuous evaluation of neonatal convulsions and gives valuable prognostic information on neurological recovery ...
Haiyan Ding, Ye, Datian, Datian Ye, Hou, Xinlin, Zhang, Dandan, Yunfeng Liu, Ding, Haiyan, Liu, Yunfeng, Zhou, Congle, Dandan Zhang, Congle Zhou, Xinlin Hou   +11 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Convulsions [PDF]

Proceedings of the Royal Society of Medicine, 1942
openaire   +2 more sources

Benign convulsions with mild gastroenteritis in children: An emerging acute symptomatic seizures

Pediatric Discovery
Benign convulsions with mild gastroenteritis (CwG) characterized by afebrile seizures that occurred in the acute period of mild gastroenteritis often occur in infancy and toddlers.
Duan Wang, Lijuan Peng, Tingsong Li, Nong Xiao   +3 more
doaj   +1 more source

Nurses’ Knowledge Regarding Pediatric Febrile Convulsions and its Nursing Care [PDF]

Introduction: A seizure that happens in children who have a high body temperature is called a febrile convulsion. The most prevalent neurological condition in children, febrile convulsions are thought to be a major contributor to hypoxia and recurrent ...
E. Ahmed, Fatima, Nor-Aldaiem, Yassin H. M., Zroog, Susan A.   +2 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Pertussis Immunization and Convulsions

, 1988
A follow-up study of 18 infants and children who suffered convulsions (9 cases) or “hypotonic-hyporesponsive“ episodes (9 cases) within 48 hours following DTP immunization was conducted in the Depts of Pediatrics, UCLA Hospital and Clinics, and the ...
J Gordon Millichap
core   +1 more source