Results 31 to 40 of about 12,033 (266)
Сельскохозяйственные машины и технологии, 2019 In order to evaluate the initial requirements for a coolant when designing an installation for obtaining the energy of the “water – ice” phase transition, it is necessary to conduct experimental studies on the thermophysical and electrophysical ...
I. G. Ershova +2 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Modeling and Visualization of Coolant Flow in a Fuel Rod Bundle of a Small Modular Reactor
FluidsThis article presents the results of an experimental study of the coolant flow in a fuel rod bundle of a nuclear reactor fuel assembly of a small modular reactor for a small ground-based nuclear power plant.
Sergei Dmitriev +8 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Applied SciencesThe paper deals with an experimental investigation of a new approach for cooling the external heat exchange surfaces of a cooler using an air pressure nozzle system.
Marek Lipnický, Zuzana Brodnianská
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
A Review of Nanofluids as Coolants for Thermal Management Systems in Fuel Cell Vehicles
Nanomaterials, 2023 With the development of high-power fuel cell vehicles, heat dissipation requirements have become increasingly stringent. Although conventional cooling techniques improve the heat dissipation capacity by increasing the fan rotating speed or radiator ...
Qi Tao +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
COOLANT FLOW DISTRIBUTION PERMEATION OF COOLANT THROUGH GRAPHITE [PDF]
, 1960 An investigation was conducted to determine the effects of He leakage through EGCR moderator columns and fuel element sleeves on the core coolant flow distribution reported in study II-179-1. Results of the investigation are discussed and recommendations for design changes so that the total coolant bypass will remain the same as previously reported are
openaire +2 more sources