Results 51 to 60 of about 121,796 (309)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Design and Fabrication of Four-Way Hacksaw

open access: yesEngineering Proceedings
Automatic power hacksaws are made for cutting different materials into different sizes. The main aim of making this machine is to save human effort, space, and time when cutting various materials to increase the amount of work that can be carried out.
P. H. J. Venkatesh   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Modeling of Separation with Drying Processes for Compressed Air Using an Experimental Setup with Separation–Condensation and Throttling Devices

open access: yesEnergies
In modern industrial plants, compressed air is the most commonly used energy source; however, it is a source of condensation, which is not desirable for pneumatic equipment.
Oleksandr Liaposhchenko   +4 more
doaj   +1 more source

Dirt analysis on the performance of an engine cooling system

open access: yesJournal of Energy in Southern Africa, 2017
This present work looked at the effect of sand blocking the heat transfer area of the radiator and its effect on the engine coolant through the conduct of experiments and a mathematical model developed.
Yashvir Singh, Nishant Kr. Singh
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Investigation into tt technological properties of coolants with liquid crystal additives / Tepimo ir aušinimo skysčio su skystųjų kristalų priedais technologinių savybių tyrimas

open access: yesMokslas: Lietuvos Ateitis, 2012
The paper presents the results of comparative research on the roughness and tool life of the machined surface when steel and cast iron work pieces were turned, reamed and tapped and the cutting zone was lubricated by various coolants (mineral oils, oil ...
Vaidas Strolia   +2 more
doaj   +1 more source

Experimental Comparison Between Conventional Coolants and (TiO2/Water) Nano fluid to select the best Coolant for Automobiles in Iraq's Summer Season [PDF]

open access: yesEngineering and Technology Journal, 2016
This work, presentsnanofluids as a new coolant technology in automobile engines compared with other conventional coolants (Ethylene glycol/water(antifreeze), distilled water) experimentally.The increase in thermal conductivity of the base fluid (water ...
Abdulmunem R. Abdulmunem
doaj   +1 more source

The effect of piston bowl temperature on diesel exhaust emissions [PDF]

open access: yes, 2005
In modern, high-speed, direct injection diesel engines for passenger vehicles, there is extensive impingement of the fuel sprays on to the piston bowl walls.
Ladommatos, N, Xiao, Z, Zhao, H
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

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