Results 31 to 40 of about 394,878 (269)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The CellML Metadata Framework 2.0 Specification

Journal of Integrative Bioinformatics, 2015
The CellML Metadata Framework 2.0 is a modular framework that describes how semantic annotations should be made about mathematical models encoded in the CellML (www.cellml.org) format, and their elements.
Cooling Michael T., Hunter Peter
doaj   +1 more source

Measuring the coolness of interactive products: the COOL questionnaire [PDF]

Behaviour & Information Technology, 2016
Coolness has recently started to be explored as a design goal for interactive products from practitioners as well as researchers within human–computer interaction (HCI), but there is still a need to further operationalise the concept and explore how we can measure it. Our contribution in this paper is the COOL questionnaire.
Anders Bruun, Dimitrios Raptis, Jesper Kjeldskov, Mikael B. Skov   +3 more
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Ensemble of global climate simulations for temperature in historical, 1.5 °C and 2.0 °C scenarios from HadAM4

Scientific Data
Large ensembles of global temperature are provided for three climate scenarios: historical (2006–16), 1.5 °C and 2.0 °C above pre-industrial levels. Each scenario has 700 members (70 simulations per year for ten years) of 6-hourly mean temperatures at a ...
Jesús Lizana, Nicole D. Miranda, Sarah N. Sparrow, Peter A. G. Watson, Miriam Zachau Walker, David C. H. Wallom, Malcolm D. McCulloch   +6 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Canadian Broadcasting Policy, Capitalism, and CanCon

Canadian Journal for the Academic Mind
In April of 2023, Bill C-11, the Online Streaming Act, was given Royal Assent to amend Canada’s 1991 Broadcasting Act to regulate transnational, American-based online streaming services that lack intrinsic reason to enhance and foster conceptions of a ...
Christine Rose Cooling
doaj   +1 more source

Air-conditioning in New Zealand: power and policy

Buildings & Cities, 2022
Policies, codes, standards and voluntary ‘green’ assessments have exacerbated cooling demand in New Zealand’s commercial buildings. Building codes allow designs to use single glazing on the facade, voluntary ‘green’ criteria are not higher than the legal
Hugh Byrd, Steve Matthewman, Eziaku Rasheed   +2 more
doaj   +1 more source

Sorption cooling: a valid extension to passive cooling

SPIE Proceedings, 2007
Passive cooling has shown to be a very dependable cryogenic cooling method for space missions. Several missions employ passive radiators to cool down their delicate sensor systems for many years, without consuming power, without exporting vibrations or producing electromagnetic interference.
Doornink, D.J., Burger, J.F., ter Brake, H.J.M.   +2 more
openaire   +2 more sources