Results 41 to 50 of about 58,339 (283)
Ecology and Evolution, 2023 Climate refugia can serve as remnant habitat for cold‐adapted species and delay forest transitions. The world's largest freshwater lake by surface area, Lake Superior, serves as a model system for understanding cooling‐mediated refugia effects, as its ...
Ashley Hillman, Scott E. Nielsen
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Observed trends of heating and cooling degree-days in Xinjiang Province, China [PDF]
, 2009 Global warming has the potential to impact various aspects of human society such as agriculture, construction, transportation, water resources management, power generation, and phenology.
Binggan +9 more
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Estimating Cooling and Heating Degree Days for Variable Base Temperature
Korean Journal of Air-Conditioning and Refrigeration Engineering, 2014 Abstract In general, building energy performance is evaluated with a detailed transient building energy simulation program. However, energy evaluation tools with the bin method are still used, because of their simple and easy way to calculatebuilding energy performance, without reducing their precision.
Pyeongchan Ihm +2 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Analysis of cooling and heating degree days in the United States from 2015 to 2024 [PDF]
E3S Web of ConferencesA sizable portion of the electricity consumed in buildings is due to the thermal load associated with the location of these buildings. Specific environmental characteristics can be translated into factors that allow researchers to understand the ...
Barbosa Priscila M. +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source
Electricity Demand of Pakistan in the Context of Cooling Degree Days: 1972-2022
, 2023 Background: Pakistan faces a critical reliance on electricity for socio-economic development and its commitment to achieving sustainable energy goals. The investigation of robust electricity demand requires the inclusion of the effects of climate change ...
Arshed, Noman, Hanif, Uzma, Sawar, Aneeq
core +1 more source