Results 121 to 130 of about 874,631 (295)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Peer Action Coordination in Middle Childhood: A Replication Null Finding on Emotion Understanding and Inhibitory Control

Behavioral Sciences
Peer action coordination in middle childhood is thought to benefit from socio-cognitive abilities such as emotion understanding and inhibitory control, but empirical evidence for their role is limited.
Giulia Barresi, Karine Maria Porpino Viana, Tone Kristine Hermansen, Beatrice Ragaglia, Daniela Bulgarelli   +4 more
doaj   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The impact of meta-stereotypes on older adults' cooperative behavior and the role of vicarious intergroup contact

Acta Psychologica
As population aging accelerates, intergroup relations between older adults and younger people have gained societal attention. Prosocial interactions, especially cooperative behavior between the two groups, significantly impact intergenerational ...
Lu Liu, Yi Guo, Shuling Chen, Xiaoyang Yang   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Correlation between Nurse /Manager Professional Collaborative Behaviors and Nurses’ Job Satisfaction

نشریه پرستاری ایران, 2018
Background & Aim: Professional collaboration play an important role in workplace’ health in healthcare organizations. Improving this collaboration may effect on nursing job satisfaction. This study aimed to determine the correlation between nurse/manager
N Pasyar, M Rambod, S Gholamzadeh, F Sharif   +3 more
doaj  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Human cooperative behavior

, 2004
Contents Summary 7 Zusammenfassung 11 Introduction 1 Cooperation 17 2 Game Theory 18 3 General approach to testing 20 4 Thesis outline 23 Chapters I Donors to charity gain in both indirect reciprocity and political 29 reputation II Reputation helps solve the 'tragedy of the commons' 37 III Volunteering leads to rock-paper-scissors dynamics in a public ...
openaire   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source