Results 111 to 120 of about 4,612,230 (303)
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
The Effect of Moral Judgment on Bystander Cooperation Behavior: The Role of Personal Force
Behavioral SciencesBackground: While extensive research has examined the antecedents of utilitarian moral judgment, its subsequent social consequences remain less explored.
Xiaodan Xu +6 more
doaj +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Sultan Qaboos University Medical Journal, 2012 Objectives: Although team-based learning (TBL) is widely used in medical education, its evaluation from the perspectives of the students exposed to it has been limited.
Ibrahim M Inuwa
doaj
Behavioral SciencesPrevious research on utilitarianism has focused predominantly on instrumental harm while neglecting the investigation of impartial beneficence. This study designed three progressive experiments (total n = 1378) to explore how impartial beneficence ...
Xiaodan Xu +5 more
doaj +1 more source
Aging and Cancer, EarlyView.This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Behavioral SciencesPeer action coordination in middle childhood is thought to benefit from socio-cognitive abilities such as emotion understanding and inhibitory control, but empirical evidence for their role is limited.
Giulia Barresi +4 more
doaj +1 more source