Results 91 to 100 of about 177,076 (305)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Manager Power, Member Behavior and Capital Structure: Portuguese Douro Wine Cooperatives [PDF]

open access: yes
Leverage is one of the most important financial factors to the survival and viability of agricultural cooperatives (e.g., wine cooperatives) during a period of intense competition.
Caldas, Jose Vaz   +2 more
core   +1 more source

Weight control follow-up - March [PDF]

open access: yes, 1983
Consists of information on weight control, diet, exercise, and behavior modification.
Taper, L. Janette
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Weight control follow-up - February [PDF]

open access: yes, 1983
Consists of information on weight control, diet, exercise, and behavior modification.
Taper, L. Janette
core  

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

AGRICULTURAL COOPERATIVE MANAGERS AND THE BUSINESS ENVIRONMENT [PDF]

open access: yes
Managers of agricultural cooperatives were contacted to determine their knowledge/capabilities and perspectives of the cooperative environment with special emphasis given to the importance of cooperative principles to the operation and success of the ...
Green, Thomas Wade, Adrian, John L., Jr.
core   +1 more source

Weight control follow-up - April [PDF]

open access: yes, 1983
Consists of information on weight control, diet, exercise, and behavior modification.
Taper, L. Janette
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Cooperative Strategies in Groups of Strangers: An Experiment [PDF]

open access: yes
We study cooperation in four-person economies of indefinite duration. Subjects interact anonymously playing a prisoner’s dilemma. We identify and characterize the strategies employed at the aggregate and at the individual level.
Marco Casari   +2 more
core  

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