Results 51 to 60 of about 20,924 (291)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Compensatory Breeding in Years Following Drought in a Desert-Dwelling Cooperative Breeder

Frontiers in Ecology and Evolution, 2020
Variation in weather patterns can influence reproductive effort and success not only within but also between breeding seasons. Where environmental conditions can be highly variable between years, the weather, and particularly extreme weather events such ...
Amanda R. Bourne, Susan J. Cunningham, Claire N. Spottiswoode, Claire N. Spottiswoode, Amanda R. Ridley, Amanda R. Ridley   +5 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Genome-Wide Association Study Reveals Genetic Loci, Candidate Genes and Favorable Haplotypes for Important Agronomic Traits in Auricularia cornea

Journal of Fungi
Auricularia cornea is rich in nutrients and bioactive compounds, and with the continuous expansion of its industrial cultivation, elucidating the genetic basis of key agronomic traits is essential for marker-assisted breeding and cultivar improvement. In
Xu Sun, Lixin Lu, Fangjie Yao, Ming Fang, Xiaoxu Ma, Yuling Cui, Jian Sun, Xianqi Shan, Wei Liu   +8 more
doaj   +1 more source

Coaction vs. Reciprocal Cooperation Among Unrelated Individuals in Social Cichlids

Frontiers in Ecology and Evolution, 2020
Members of social groups often temporally coordinate their behaviors, for instance in defense or foraging. In the context of cooperation, simultaneous or sequential coordination of behavior may allow social partners to adjust their cooperative effort ...
Michael Taborsky, Thomas Riebli
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Caregivers recognize and bias response towards individual young in a cooperative breeding mammal, the banded mongoose

, 2008
In research on parental care and cooperative breeding an issue is whether caregivers recognize individual young and therefore preferentially care for those young that will maximize inclusive fitness gains.
Gilchrist, J.S., Mwanguhya, F., Otali, E.   +2 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

New Species, New Record, and Antagonistic Potential of Torula (Torulaceae, Pleosporales) from Jilin Province, China

Microorganisms
During a survey of ascomycetous fungi associated with plant litter and submerged wood in Jilin Province, China, two hyphomycetous fungi were discovered. Morphological examination and molecular phylogenetic analyses revealed that these isolates represent ...
Rong Xu, Yue Zhang, Wenxin Su, Yu Li
doaj   +1 more source