Results 61 to 70 of about 1,124,065 (284)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Compensatory Breeding in Years Following Drought in a Desert-Dwelling Cooperative Breeder
Frontiers in Ecology and Evolution, 2020 Variation in weather patterns can influence reproductive effort and success not only within but also between breeding seasons. Where environmental conditions can be highly variable between years, the weather, and particularly extreme weather events such ...
Amanda R. Bourne +5 more
doaj +1 more source
Individual variation in cooperative behaviour in meerkats [PDF]
, 2010 Individual variation in cooperation is a striking yet poorly understood feature of many animal societies, particularly in cooperative breeders where individuals assist in the care of young that are not their own.
core +2 more sources
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Virginia Cooperative Extension Volunteers: Extending Knowledge and Improving Lives Updates
, 2021 This is an informational brochure describing Virginia Cooperative Extension volunteer programs, and screening requirements for potential VCE volunteers ...
Proudfoot, Chad
core
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
MicroorganismsDuring a survey of ascomycetous fungi associated with plant litter and submerged wood in Jilin Province, China, two hyphomycetous fungi were discovered. Morphological examination and molecular phylogenetic analyses revealed that these isolates represent ...
Rong Xu, Yue Zhang, Wenxin Su, Yu Li
doaj +1 more source
Coaction vs. Reciprocal Cooperation Among Unrelated Individuals in Social Cichlids
Frontiers in Ecology and Evolution, 2020 Members of social groups often temporally coordinate their behaviors, for instance in defense or foraging. In the context of cooperation, simultaneous or sequential coordination of behavior may allow social partners to adjust their cooperative effort ...
Michael Taborsky, Thomas Riebli
doaj +1 more source
Reproductive senescence in a cooperatively breeding mammal [PDF]
Journal of Animal Ecology, 2009 Summary 1. Senescence (or ‘ageing’) is a widespread and important process in wild animal populations, but variation in ageing patterns within and between species is poorly understood. 2. In cooperatively breeding species, the costs of reproduction are shared between breeders and one or more helpers.
Sharp, Stuart P., Clutton-Brock, Tim H.
openaire +2 more sources
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source