Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Necessary and Sufficient Conditions for Pareto Optimality in Infinite Horizon Cooperative Differential Games [PDF]
In this article we derive necessary and sufficient conditions for the existence of Pareto optimal solutions for infinite horizon cooperative differential games. We consider games defined by non autonomous and discounted autonomous systems.
Engwerda, J.C., Reddy, P.V.
core +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Group consensus in generic linear multi-agent systems with inter-group non-identical inputs
Cogent Engineering, 2014 This paper studies the group consensus problem for generic linear multi-agent systems under directed information flow. External adapted inputs are introduced to realize the intra-group synchronization as well as the inter-group separation.
Yilun Shang
doaj +1 more source
Adaptive Fuzzy Event-Triggered Cooperative Control for Multi-Robot Systems: A Predefined-Time Strategy. [PDF]
Sensors (Basel), 2023 Tian X, Huang X, Liu H, Mai Q.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu +11 more
wiley +1 more source
Cooperative Control of Underwater Vehicle-Manipulator Systems Based on the SDC Method. [PDF]
Sensors (Basel), 2022 Kabanov A +3 more
europepmc +1 more source
Are Traditional Cooperatives an Endangered species? About Shrinking Satisfaction, Involvement and Trust [PDF]
Several researchers, who have observed that traditional cooperatives have difficulties in modern markets, mention a number of behavioral concepts characterizing the members. This study attempts to empirically test these concepts.
Kihlen, Anna +2 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Optimal-Damage-Effectiveness Cooperative-Control Strategy for the Pursuit-Evasion Problem with Multiple Guided Missiles. [PDF]
Sensors (Basel), 2022 Ma X +7 more
europepmc +1 more source