Results 71 to 80 of about 10,201,580 (262)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Joint Analysis of the Commuting Departure Time and Travel Mode Choice: Role of the Built Environment

Journal of Advanced Transportation, 2018
This paper aims to conduct an empirical study to evaluate the influence of built environment features and socioeconomic factors on commuters’ simultaneous choice of departure time and travel mode.
Xiaolei Ma, Jie Yang, Chuan Ding, Jianfeng Liu, Quan Zhu   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A geospatial dataset of PFOS and PFOA occurrence records in China’s multi-media environments (2021–2024)

Scientific Data
Per- and polyfluoroalkyl substances (PFAS), particularly the legacy compounds Perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), are globally ubiquitous persistent organic pollutants that pose significant health risks. Although these
Xiaolong Wu, Yiyang Guo, Yinsheng Zhang, Sen Li   +3 more
doaj   +1 more source

The Utilization of Indoleacetic Acid to Enhance the Tolerance of Microalgae to Antibiotics, Removal Capability, and Lipid Production

Microorganisms
The utilization of microalgae for bioremediation presents a highly promising and cost-effective approach, offering advantages of simultaneous pollutant removal and biomass recovery.
Lifeng Wang, Yibo Zhang, Zhenbing Wu, Chenyuan Dang, Jie Fu   +4 more
doaj   +1 more source

Virginia Cooperative Extension Peer Reviewer Feedback Form

, 2016
This document provides guidelines for reviewing quality and accuracy of text, and illustrations in manuscripts under consideration for publication by Virginia Cooperative ...

core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Analytical Model of Spread of Epidemics in Open Finite Regions

IEEE Access, 2017
Epidemic dynamics, a kind of biological mechanisms describing microorganism propagation within populations, can inspire a wide range of novel designs of engineering technologies, such as advanced wireless communication and networking, global immunization
Daxin Tian, Chao Liu, Zhengguo Sheng, Min Chen, Yunpeng Wang   +4 more
doaj   +1 more source

Virginia Cooperative Extension Volunteers: Extending Knowledge and Improving Lives

, 2015
This publication reviews the volunteer screening process for the Virginia Cooperative ...

core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source