Results 81 to 90 of about 10,201,580 (262)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Spatial Copula Model for Imputing Traffic Flow Data from Remote Microwave Sensors
Sensors, 2017 Issues of missing data have become increasingly serious with the rapid increase in usage of traffic sensors. Analyses of the Beijing ring expressway have showed that up to 50% of microwave sensors pose missing values.
Xiaolei Ma, Sen Luan, Bowen Du, Bin Yu
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Characteristics of Waste Wind Turbine Blades and Development Trends of Recycling Technologies
能源环境保护The rapid growth of renewable energy, particularly wind power, has led to the large-scale construction and operation of wind farms. By the end of 2024, the global installed wind power capacity had reached 1 136 GW, with China leading the world by ...
Shifa ZHOU +7 more
doaj +1 more source
An Automatic Car Accident Detection Method Based on Cooperative Vehicle Infrastructure Systems
IEEE Access, 2019 Car accidents cause a large number of deaths and disabilities every day, a certain proportion of which result from untimely treatment and secondary accidents.
Daxin Tian +3 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Current Situation and Development Trend of End-of-life Photovoltaic Module Treatment and Disposal
能源环境保护The adoption of clean energy, particularly solar energy, serves as a critical measure for achieving the dual-carbon goals. By the end of 2023, China′s cumulative installed solar capacity had reached 609 GW, with projections indicating a rise to ...
Shifa ZHOU +7 more
doaj +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source