Results 51 to 60 of about 67,451 (260)

Evolution of cooperation with the diversity of cooperation tendencies

Chaos, Solitons & Fractals
The complete cooperation and the complete defection are two typical strategies considered in evolutionary games in many previous works. However, in real life, strategies of individuals are full of variety rather than only two complete ones. In this work, the diversity of strategies is introduced into the weak prisoners' dilemma game, which is measured ...
Huang, Linya, Han, Wenchen
openaire   +2 more sources

Diversity-optimized cooperation on complex networks

Physical Review E, 2009
We propose a strategy for achieving maximum cooperation in evolutionary games on complex networks. Each individual is assigned a weight that is proportional to the power of its degree, where the exponent alpha is an adjustable parameter that controls the level of diversity among individuals in the network. During the evolution, every individual chooses
Yang, Han-Xin, Wang, Wen-Xu, Wu, Zhi-Xi, Lai, Ying-Cheng, Wang, Bing-Hong   +4 more
openaire   +4 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Superposition Network Coding for Wireless Cooperative Communication

International Journal of Information and Communication Technology Research, 2013
Spatial diversity can be exploited by the use of cooperative communication technology. However, most of the well known cooperative protocols have some practical challenges.
Ali Fazeli, Mohammad Javad Omidi, Hamid Saeedi Sourck   +2 more
doaj  

Metric-Based Cooperative Routing in Multihop Ad Hoc Networks

Journal of Computer Networks and Communications, 2012
Cooperative communication fully leverages the broadcast nature of wireless channels and exploits time/spatial diversity in a distributed manner, thereby achieving significant improvements in system capacity and transmission reliability.
Xin He, Frank Y. Li
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Research on cognitive user pairing and cooperative sensing

Tongxin xuebao, 2012
Aim at the shortages of the cooperative algorithm in sensing and time slot spent,an optimal cognitive users pairing and cooperative sensing algorithm was proposed.To achieve the best sensing performance,the pairing criterion was adopted where the one ...
Zhi-hua BAO, Shi-bing ZHANG, Xiao-ge ZHANG, Gong-an QIU   +3 more
doaj