Results 41 to 50 of about 193,411 (276)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Characterizing the emission trends and pollution evolution patterns during the transition period following COVID-19 at an industrial megacity of central China

Ecotoxicology and Environmental Safety
After the resumption of work and production following the COVID-19 pandemic, many cities entered a “transition phase”, characterized by the gradual recovery of emission levels from various sources.
Yafei Li, Lu Yao, Jingyi Yang, Jianhui Wu, Xiao Tang, Shengwen Liang, Yufen Zhang, Yinchang Feng   +7 more
doaj   +1 more source

Dynamic Optimal Control of Transboundary Pollution Abatement under Learning-by-Doing Depreciation

Complexity, 2020
This paper analyzes a dynamic Stackelberg differential game model of watershed transboundary water pollution abatement and discusses the optimal decision-making problem under non-cooperative and cooperative differential game, in which the accumulation ...
Zhigang Chen, Rongwei Xu, Yongxi Yi
doaj   +1 more source

Cooperativity of a few quantum emitters in a single-mode cavity [PDF]

, 2013
We theoretically investigate the emission properties of a single-mode cavity coupled to a mesoscopic number of incoherently pumped quantum emitters. We propose an operational measure for the medium cooperativity, valid both in the bad and in the good ...
Auffèves, Alexia, Gerace, Dario, Mascarenhas, Eduardo, Santos, Marcelo França   +3 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Design of a low carbon economy model by carbon cycle optimization in supply chain

Frontiers in Ecology and Evolution, 2023
IntroductionConcerning economic globalization, enterprises must work with the cooperative partner to obtain more profits and overall planning of the supply chain has become a new focus for enterprise development.
Jingwen Ding
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Coherent control of the cooperative branching ratio for nuclear x-ray pumping

, 2011
Coherent control of nuclear pumping in a three level system driven by x-ray light is investigated. In single nuclei, the pumping performance is determined by the branching ratio of the excited state populated by the x-ray pulse.
Adriana Pálffy, B. Adams, Christoph H. Keitel, D. Barb, G. C. Baldwin, J. P. Hannon, Jörg Evers, M. Afanas’ev, M. Afanas’ev, M. Altarelli, M. O. Scully, R. B. Firestone, R. Röhlsberger, S. A. Karamian, Z. Ficek   +14 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Neutrino Emission from Cooper Pairs at Finite Temperatures [PDF]

Advances in High Energy Physics, 2018
A brief review is given of the current state of the problem of neutrino pair emission through neutral weak currents caused by the Cooper pairs breaking and formation (PBF) in superfluid baryon matter at thermal equilibrium. The cases of singlet-state pairing with isotropic superfluid gap and spin-triplet pairing with an anisotropic gap are analyzed ...
openaire   +3 more sources