Results 141 to 150 of about 44,575 (317)

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao   +8 more
wiley   +1 more source

Double-layer energy transaction strategy of multi-microgrids and distribution network with leased shared energy storage

open access: yesDiance yu yibiao
To solve the challenges of imbalanced distribution of benefits among various interested parties during the cooperative operation of multi-microgrids under the same distribution network.
WANG Hui   +4 more
doaj   +1 more source

The Core of an Extended Tree Game: A New Characterisation [PDF]

open access: yes
Cost allocation problems on networks can be interpreted as cooperative games on a graph structure. In the classical standard tree game, the cost of a service delivered, by a source has to be allocated between homogeneous users at the vertices.
Barbara von Schnurbein
core  

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

open access: yesAdvanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang   +4 more
wiley   +1 more source

Non-Cooperative Representations of Cooperative Games

open access: yesGames
Non-cooperative games in normal form are specified by a player set, sets of player strategies, and payoff functions. Cooperative games, meanwhile, are specified by a player set and a worth function that maps coalitions of players to payoffs they can feasibly achieve.
openaire   +1 more source

On core stability and extendability

open access: yes, 2007
Shellshear E. On core stability and extendability. Working Papers. Institute of Mathematical Economics. Vol 387. Bielefeld: Universität Bielefeld; 2007.This paper investigates conditions under which the core of a TU cooperative game is stable.
Shellshear, Evan
core  

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

open access: yesAdvanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng   +17 more
wiley   +1 more source

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