Results 31 to 40 of about 904,877 (286)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

MENINGKTKAN MOTIVASI BELAJAR MAHASISWA KEPERAWATAN MELALUI METODE PEMBELAJARAN COOPERATIVE LEARNING

IJNP (Indonesian Journal of Nursing Practices), 2016
One of factors that determine student success in learning is the selection of appropriate learning method. Learning methods that are not boring for the students is one learning method that can improve student learning motivation that ultimately might ...
Sylvie Puspita, Neny Triana
doaj   +1 more source

PERBEDAAN KEMAMPUAN KOGNITIF DAN KETERAMPILAN KOOPERATIF DALAM PEMBELAJARAN KOOPERATIF MODEL JIGSAW DAN COOPERATIV SCRIPT SISWA KELAS VIII MTS MUHAMMADIYAH 1 MALANG [PDF]

, 2009
Cooperative learning is a study which focused on cooperation among students to reach learning goal. Cooperative learning with Jigsaw Model and Cooperative Script were two cooperative learning model which had many characteristic similarity.
NUR ILMA, ALFIN
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

EFEKTIVITAS METODE PROBLEM BASED LEARNING, COOPERATIVE LEARNING TIPE JIGSAW, DAN CERAMAH SEBAGAI PROBLEM SOLVING DALAM MATAKULIAH PERENCANAAN PEMBELAJARAN

Cakrawala Pendidikan: Jurnal Ilmiah Pendidikan, 2013
Abstrak: penelitian ini bertujuan untuk mengetahui efektivitas metode pembelajaran Problem Based Learning, Cooperative Learning tipe jigsaw, dan ceramah dalam pembelajaran matakuliah Perencanaan Pembelajaran di Fakultas Tarbiyah UIN Makassar, baik dalam ...
Fatimah Saguni
doaj   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

The Impact of Think Pair Share Model on Mathematics Learning in Elementary Schools [PDF]

, 2019
One objective of mathematics learning is to solve problem and to communicate idea to get a solution. Human life is inseparable from social activity, including cooperation. Similarly, in mathematics learning sometimes students need friends to discuss with
Ardiyani, S. M. (Shila), Gunarhadi, G. (Gunarhadi), Riyadi, R. (Riyadi)   +2 more
core  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Cooperative Learning vs. Direct Instruction: Using two Instructional Models to Determine their Impact on Student Learning in a Middle School Math Classroom [PDF]

, 2012
This research project is being conducted to find out what type of instruction is more beneficial to student learning and involvement in the field of mathematics.
Duff, Jenna
core   +2 more sources