Results 121 to 130 of about 163,389 (278)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Cooperative Localization under Ionospheric Scintillation Events

EURASIP Journal on Advances in Signal Processing
Ionospheric scintillation causes major impairments to Global Navigation Satellite System (GNSS) in low-latitude regions. In severe scenarios, this event can lead to complete loss of lock, thus making GNSS measurements unusable for navigation.
Paulo R. P. Silva, Marcelo G. S. Bruno, Alison O. Moraes   +2 more
doaj   +1 more source

Comparative Analysis of Centralized and Federated Learning Techniques for Sensor Diagnosis Applied to Cooperative Localization for Multi-Robot Systems. [PDF]

Sensors (Basel), 2023
El Mawas Z, Cappelle C, Daher M, El Badaoui El Najjar M.   +3 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Wideband Cooperative Localization Through Generalized Cross-Correlation

IEEE Access
This work proposes a novel algorithm for robust cooperative localization using wideband time difference of arrival (TDoA) measurements and information coupling between nodes.
Andreas Fuchs, Lukas Wielandner, Klaus Witrisal   +2 more
doaj   +1 more source

A Scalable Framework for Map Matching Based Cooperative Localization. [PDF]

Sensors (Basel), 2021
Yang C, Strader J, Gu Y.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Cooperative Localization Using Distance Measurements for Mobile Nodes. [PDF]

Sensors (Basel), 2021
Li W, Jelfs B, Kealy A, Wang X, Moran B.
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source