Results 31 to 40 of about 2,174,158 (275)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart

Scientific Reports, 2022
2-Deoxy-D-glucose (2DG) has recently received emergency approval for the treatment of COVID-19 in India, after a successful clinical trial. SARS-CoV-2 infection of cultured cells is accompanied by elevated glycolysis and decreased mitochondrial function,
Irati Aiestaran-Zelaia, María Jesús Sánchez-Guisado, Marina Villar-Fernandez, Mikel Azkargorta, Lucia Fadon-Padilla, Uxoa Fernandez-Pelayo, Diego Perez-Rodriguez, Pedro Ramos-Cabrer, Antonella Spinazzola, Félix Elortza, Jésus Ruíz-Cabello, Ian J. Holt   +11 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Formation, “Gold Rule” for the cooperative development

Cooperativismo y Desarrollo, 2013
Before the arising of the cooperative movement in the world, cooperation already existed. So, it is logical to affirm that there can be cooperation without cooperative movement.
Alcides López Labrada
doaj  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Cooperatives and the State: The Case of Ontario

Canadian Journal of Nonprofit and Social Economy Research, 2011
In the early 2000s, the cooperative movement in Ontario came together in order to lobby its provincial government for active cooperative development support programs. Momentum was building for these types of programs. Already, many provincial governments
Rachel Laforest, Jen Heneberry
doaj   +3 more sources

The role of the orthodox clergy of the Right Bank Ukraine in the protection of the rights and freedoms of the peasantry (second half of the 19th – the beginning of the 20th century)

Науковий вісник Чернівецького національного університету імені Юрія Федьковича. Історія, 2020
In the middle of the 19th century among the Orthodox clergy of the Ukrainian dioceses of the ROC, there was a clear division between the Orthodox, who served the interests of the autocracy and opposed the reforms of the church and its ukrainization, and
Олексій Кошель
doaj  

A cooperative lane change model for connected and autonomous vehicles on two lanes highway by considering the traffic efficiency on both lanes

Transportation Research Interdisciplinary Perspectives, 2021
Lane change maneuver is one of the critical resources of traffic oscillation which will jeopardize traffic efficiency and safety. Emergent connected and autonomous vehicle (CAV) technology provides the opportunity to cooperate with CAV movements and ...
Kang Sun, Xiangmo Zhao, Xia Wu
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source