Results 81 to 90 of about 60,064 (306)
Inactivation gating of Kv7.1 channels does not involve concerted cooperative subunit interactions
Channels, 2018 Inactivation is an intrinsic property of numerous voltage-gated K+ (Kv) channels and can occur by N-type or/and C-type mechanisms. N-type inactivation is a fast, voltage independent process, coupled to activation, with each inactivation particle of a ...
Eshcar Meisel +5 more
doaj +1 more source
Quantifying Cooperativity in Mutated Collagen [PDF]
, 2014 Many biological systems can be considered coupled systems, arising from the interconnected structure of on (or more) molecular/protein components. An important characteristic of any such “built up” macromolecule is the need for synergistic behavior ...
Kwan, Kenny, Cranford, Steven
core
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
Hidden Structural Modules in a Cooperative RNA Folding Transition
Cell Reports, 2018 Summary: Large-scale, cooperative rearrangements underlie the functions of RNA in RNA-protein machines and gene regulation. To understand how such rearrangements are orchestrated, we used high-throughput chemical footprinting to dissect a seemingly ...
Brant Gracia +5 more
doaj +1 more source
Aging and Cancer, EarlyView.This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source
Copper Increases the Cooperative Gating of Rat P2X2a Receptor Channels
PharmaceuticalsBackground/Objectives: P2X receptor channels are widely expressed in the CNS, where they have multiple functions in health and disease. The rat P2X2a (rP2X2a) receptor channel is modulated by copper, an essential trace element that plays important roles ...
Elias Leiva-Salcedo +3 more
doaj +1 more source
Summary of terms for cooperativity and ligand depletion.
, 2013 Summary of terms for cooperativity and ligand depletion.
Nicolas Le Novère (14063) +2 more
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Direct Measurement of Tertiary Contact Cooperativity in RNA Folding
, 2016 Direct Measurement of Tertiary Contact Cooperativity in RNA ...
Steven Chu (6618) +4 more
core +1 more source
Cooperativity Has Empirical and Ultimate Levels of Explanation [PDF]
, 2016 Controversy over the meaning of pharmacological parameters often arises because of a lack of appreciation of different hierarchical levels of analysis. In a recent letter in Trends in Pharmacological Sciences, Zhang and Kavana [1] concluded that my two ...
Ehlert, Frederick J
core +1 more source