Results 131 to 140 of about 116,296 (308)

Mapping Ground-based Coronagraphic Images to Helioprojective-Cartesian Coordinate System by Image Registration

The Astrophysical Journal
A few ground-based solar coronagraphs have been installed in western China for observing the low-layer corona in recent years. However, determining the helioprojective coordinates for the coronagraphic data with high precision is an important but ...
Feiyang Sha, Yu Liu, Lidong Xia, Yao Chen, Qing Zhou, Yangrui Chen, Chuyu Zhong, Xuefei Zhang, Tengfei Song, Mingzhe Sun, Xiaoyu Yu, Haitang Li, Jacob Oloketuyi, Qiang Liu, Xinjian Wang, Qiwang Luo, Xiaobo Li   +16 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Development of chemistry coordinate mapping approach for turbulent partially premixed combustion

, 2013
Direct numerical simulation (DNS) coupling with chemistry coordinate mapping (CCM) is presented to simulate flame propagation and auto-ignition in a partially premixed syngas/air mixture.
Yu, Rixin, Bai, X-S, Bai, Xue-Song, Jangi, Mehdi, Jangi, M., Yu, R., Bai, Xue Song   +6 more
core   +1 more source

The ANTsX ecosystem for mapping the mouse brain

Nature Communications
Large-scale efforts by the BRAIN Initiative Cell Census Network (BICCN) are generating a comprehensive reference atlas of cell types in the mouse brain.
Nicholas J. Tustison, Min Chen, Fae N. Kronman, Jeffrey T. Duda, Clare Gamlin, Mia G. Tustison, Michael Kunst, Rachel Dalley, Staci Sorenson, Quanxin Wang, Lydia Ng, Yongsoo Kim, James C. Gee   +12 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Evaluation of shape mapping accuracy for measurements performed on coordinate measuring arm equipped with optical probe

, 2011
Realizacja pomiarów może być dokonywana z wykorzystaniem różnego rodzaju technik pomiarowych. Obecnie w dobie nieustannego rozwoju technik wytwarzania i metrologii dużą rolę odgrywa możliwość dokładnej oceny mierzonego przedmiotu, a przez to odwzorowanie
Gąska, A., Olszewska, M.
core  

Hierarchical Multiscale Fusion with Coordinate Attention for Lithologic Mapping from Remote Sensing

Remote Sensing
Accurate lithologic maps derived from satellite imagery underpin structural interpretation, mineral exploration, and geohazard assessment. However, automated mapping in complex terranes remains challenging because spectrally similar units, narrow ...
Fuyuan Xie, Yongguo Yang
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source