Results 91 to 100 of about 1,986,731 (313)

The display of spatial information and visually guided behavior [PDF]

open access: yes
The basic informational elements of spatial orientation are attitude and position within a coordinate system. The problem that faces aeronautical designers is that a pilot must deal with several coordinate systems, sometimes simultaneously.
Bennett, C. Thomas
core   +1 more source

Puzzles in Time Delay and Fermat Principle in Gravitational Lensing [PDF]

open access: yes, 2011
The current standard time delay formula (CSTD) in gravitational lensing and its claimed relation to the lens equation through Fermat's principle (least time principle) have been puzzling to the author for some time.
Rhie, Sun Hong
core  

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Users manual for coordinate generation code CRDSRA [PDF]

open access: yes
Generation of a viable coordinate system represents an important component of an isolated airfoil Navier-Stokes calculation. The manual describes a computer code for generation of such a coordinate system. The coordinate system is a general nonorthogonal
Shamroth, S. J.
core   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

open access: yesMolecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides   +13 more
wiley   +1 more source

Coordination as a Paradigm for Systems Integration

open access: yesJournal of Systems Integration, 2001
105
Omicini, A.   +3 more
openaire   +3 more sources

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