Results 111 to 120 of about 1,547,336 (308)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
F1000ResearchBackground DataSHIELD is a mature, R-based federated learning platform that enables multi-site analysis without sharing individual participant data. While DataSHIELD includes many packages for data analysis, it lacks user-friendly data manipulation tools.
Eleanor Hyde +10 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
II. Noisy Equilibrium Selection in Coordination Games
, 2007 this paper is organized as follows. Section 2 describes a coordination game with continuous strategy spaces and introduces a noisy variant that we will study. This section contains the paper's main result (Proposition 1).
M. Ganslandt, Coordination Games
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Advances in Medical Education and PracticeYanpeng Jin,1,2 Yan Song,1 Xiuyuan Li,1 Haijiang Wu,1 Qin Zhang1,3 1Medical-Education Coordination and Medical Education Research Center, Hebei Medical University, Shijiazhuang, People’s Republic of China; 2Basical Medical College, Hebei North University,
Jin Y, Song Y, Li X, Wu H, Zhang Q
doaj
Nature CommunicationsMost C–H bond activations of natural gas alkanes rely on transition metal complexes. Activations by using main-group systems have been reported but required heating or photo-irradiation under high atmospheric pressure with rather low regioselectivity ...
Runbo Pei +6 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
International Coordination of Economic Policies: Scope, Methods, and Effects [PDF]
This paper discusses the scope, methods, the effects of international coordination of economic policies. In addressing the scope for and of coordination, the analysis covers the rationale for coordination, barriers to coordination, the range and ...
Morris Goldstein +2 more
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FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
When and Why? A Critical Survey on Coordination Failure in the Laboratory [PDF]
Coordination games with Pareto-ranked equilibria have attracted major theoretical attention over the past two decades. Two early path-breaking sets of experimental studies were widely interpreted as suggesting that coordination failure is a common ...
Andreas Ortmann, Giovanna Devetag
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