Results 91 to 100 of about 629,305 (401)

Prediction of disease progression, treatment response and dropout in chronic obstructive pulmonary disease (COPD). [PDF]

, 2014
Drug development in chronic obstructive pulmonary disease (COPD) has been characterised by unacceptably high failure rates. In addition to the poor sensitivity in forced expiratory volume in one second (FEV1), numerous causes are known to contribute to ...
Danhof, M, Della Pasqua, O, Facius, A, Maas, HJ, Musuamba, FT, Teutonico, D, Yang, S   +6 more
core   +1 more source

Cyclic Strain and Macrophage‐Mediated Transport Govern Micron‐Sized PM2.5 Translocation across the Air–Blood Barrier

Advanced Science, EarlyView.
Using a dynamic, tri‐culture air‐blood barrier model, this study reveals that macrophage‐mediated transport governs micron‐sized particle translocation under cyclic strain. The process is highly size‐dependent that 2 µm particles are transported by macrophages, 0.2 µm particles diffuse passively, and 5 µm particles are effectively blocked.
Yongjian Li, Jinlong Xu, Zujie Gao, Haosheng Chen   +3 more
wiley   +1 more source

Work absence in patients with asthma and/or COPD: a population-based study

npj Primary Care Respiratory Medicine, 2021
Chronic obstructive pulmonary disease (COPD) and asthma impact on work productivity, but their population-based burden and clinical predictors are understudied.
Boudewijn J. H. Dierick, Bertine M. J. Flokstra-de Blok, Thys van der Molen, Núria Toledo-Pons, Miguel Román-Rodríguez, Borja G. Cosío, Joan B. Soriano, Janwillem W. H. Kocks, Job F. M. van Boven   +8 more
doaj   +1 more source

Role of inflammatory cells in airway remodeling in COPD

International Journal of COPD, 2018
COPD is characterized by chronic bronchitis, chronic airway obstruction, and emphysema, leading to a progressive and irreversible decline in lung function. Inflammation is central for the development of COPD.
Yujie Wang, Jiayan Xu, Y. Meng, I. Adcock, X. Yao   +4 more
semanticscholar   +1 more source

Interior Decorative VOCs Elevate T Cell‐Mediated Obstructive Lung Disease Risks via Osteogenesis‐Driven Lymphoid‐Biased Hematopoiesis

Advanced Science, EarlyView.
This study utilizes a whole‐body inhalation model to reveal that interior decorative VOCs exposure persistently elevates alveolar T cells. This increase is attributed to lymphoid‐biased hematopoiesis in the bone marrow, which is further driven by IL‐6/IL‐17A‐mediated osteogenic differentiation.
Hongyan Yu, Jingxu Zhang, Qingping Liu, Duxing Li, Ruonan Pan, Gan Miao, Yidi Chen, Zhe Kou, Guangbo Qu, Rong Zhang, Xiaoting Jin, Yuxin Zheng   +11 more
wiley   +1 more source

The Fractional exhaled Nitric Oxide (FeNO)- test as add-on test in the diagnostic work-up of asthma: a study protocol

BMC Pulmonary Medicine
Background Asthma is a common disease characterized by chronic inflammation of the lower airways, bronchial hyperactivity, and (reversible) airway obstruction. The Global Initiative of Asthma Guideline recommends a flowchart to diagnose asthma with first-
T. (Tuba) Kaya, G.J. (Gert-Jan) Braunstahl, J.C.C.M. (Johannes) in ’t Veen, J.H. (Jasper) Kappen, J.P.M. (Hanna) van der Valk   +4 more
doaj   +1 more source

Mechanical ventilation in chronic obstructive pulmonary disease patients, noninvasive vs. invasive method (randomized prospective study) [Usporedba neinvazivne i invazivne umjetne ventilacije kod bolesnika s kroničnom opstruktivnom plućnom bolesti: prospektivna randomizirana studija] [PDF]

, 2009
Acute respiratory failure due to chronic obstructive pulmonary disease (COPD) presents an increasing problem throughout the world. The aim of this study was to compare invasive and non-invasive mechanical ventilation (MV) for patients with COPD.
Buković, Damir, Jurjević, Matija, Matić, Ivo, Đanić, Davorin, Šakić, Šimun, Šakić-Zdravčević, Katarina   +5 more
core  

Objective measurement of cough frequency during COPD exacerbation convalescence [PDF]

, 2015
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Cough and sputum production are associated with adverse outcomes in COPD and are common during COPD exacerbation (AE-COPD).
Crooks, Michael G., Hayman, Yvette, Innes, Andrew, Morice, Alyn H., Williamson, James, Wright, Caroline E.   +5 more
core   +1 more source

Sarcopenia in COPD: a systematic review and meta-analysis

European Respiratory Review, 2019
COPD is associated with a progressive loss of muscle mass and function. However, there is an unmet need to define and standardise methods to estimate the prevalence of sarcopenia in COPD patients. We performed a systematic review and meta-analysis of the
E. Benz, K. Trajanoska, L. Lahousse, J. Schoufour, N. Terzikhan, Emmely W. de Roos, Gerdien B de Jonge, Ross D. Williams, O. Franco, G. Brusselle, F. Rivadeneira   +10 more
semanticscholar   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source