Results 61 to 70 of about 602,916 (384)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Inflammatory endotypes in COPD

Allergy. European Journal of Allergy and Clinical Immunology, 2019
Chronic obstructive pulmonary disease (COPD) is a major global health problem that is poorly treated by current therapies as it has proved difficult to treat the underlying inflammation, which is largely corticosteroid‐resistant in most patients ...
P. Barnes
semanticscholar   +1 more source

Agreement of administrative pharmacy dispensing with self‐reported use of oral prednisone in US Veterans with rheumatoid arthritis

Arthritis Care &Research, Accepted Article.
Objective Administrative claims are used to evaluate oral glucocorticoid use in rheumatoid arthritis (RA), despite limited evidence to support accuracy. We aimed to evaluate the performance of claims‐based algorithms for glucocorticoid use compared to self‐report in an RA population.
Beth I. Wallace, Bryant R. England, Joshua F. Baker, Michael D. George, Brian C. Sauer, Jorge Rojas, Punyasha Roul, Katherine D. Wysham, Hannah Brubeck, Isaac Smith, Liron Caplan, Paul A. Monach, Gail S. Kerr, Gary Kunkel, Tawnie Braaten, Ted R. Mikuls, Grant W. Cannon   +16 more
wiley   +1 more source

AGER expression and alternative splicing in bronchial biopsies of smokers and never smokers

Respiratory Research, 2019
Cigarette smoking is one of the major risk factors for the development of chronic obstructive pulmonary disease (COPD). Evidence is accumulating that Receptor for Advanced Glycation-End products (RAGE)-signaling is a key pathway in the pathophysiology of
Alen Faiz, Maarten van den Berge, Cornelis J. Vermeulen, Nick H. T. ten Hacken, Victor Guryev, Simon D. Pouwels   +5 more
doaj   +1 more source

The effects of lung volume reduction treatment on diffusing capacity and gas exchange

European Respiratory Review, 2020
Lung volume reduction (LVR) treatment in patients with severe emphysema has been shown to have a positive effect on hyperinflation, expiratory flow, exercise capacity and quality of life.
Marlies van Dijk, Karin Klooster, Nick H.T. Ten Hacken, Frank Sciurba, Huib. A.M. Kerstjens, Dirk-Jan Slebos   +5 more
doaj   +1 more source

Six Weeks of Resveratrol Improves Cardiovascular Health in Patients with COPD [PDF]

, 2020
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. One-third of people diagnosed with COPD die of cardiovascular (CV) complications as opposed to pulmonary.
Cobb, Kolton, Goldman, Kendall, Lavender, Rebekah, Rodriguez-Miguelez PhD, Paula   +3 more
core   +1 more source

Cardiovascular disease and COPD: dangerous liaisons?

European Respiratory Review, 2018
Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) frequently occur together and their coexistence is associated with worse outcomes than either condition alone.
K. Rabe, J. Hurst, S. Suissa
semanticscholar   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Validation of new predictors of mortality and BODE index variants in patients with COPD at moderate altitude

ERJ Open Research
Background COPD ranks as the third leading global cause of mortality. Despite the widespread use of the BODE index and its variants for mortality prediction, their accuracy may be affected by factors like ethnicity, altitude and regional disparities ...
Robinson Robles-Hernández, Gustavo I. Centeno-Saenz, Alejandra Ramírez-Venegas, Ireri Thirion-Romero, Rafael Hernández-Zenteno, Sandra P. Guinto-Ramírez, María C. Maya-García, Diana Villegas-Trejo, Francisco Montiel-López, Lila M. Cordero-Silis, Rogelio Pérez-Padilla   +10 more
doaj   +1 more source

Long-term exposure to outdoor air pollution and the incidence of chronic obstructive pulmonary disease in a national English cohort. [PDF]

, 2014
OBJECTIVES: The role of outdoor air pollution in the incidence of chronic obstructive pulmonary disease (COPD) remains unclear. We investigated this question using a large, nationally representative cohort based on primary care records linked to hospital
A J Kent, Abbey, Adams, Andersen, Anderson, Atkinson, Brook, Carey, Cesaroni, D G Cook, Department of Health, Downs, Eisner, Euler, Euler, Gan, Gershon, Gotschi, Gulliver, H R Anderson, Hajat, Hoek, I M Carey, Jerrett, Krewski, Lim, Noble, Pope, R W Atkinson, Schikowski, Schikowski, Simpson, Sunyer, T P van Staa, Vienneau, Wheeler, Williams   +36 more
core   +1 more source