Results 81 to 90 of about 404,062 (356)

The COPD Pipeline

COPD: Journal of Chronic Obstructive Pulmonary Disease, 2009
Smoking Cessation. Nabi Biopharmaceuticals has received a NIDA grant of $4+ million in partial support of the next and, one hopes, final phases of a possible nicotine conjugate vaccine.
openaire   +4 more sources

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

Advanced Science, EarlyView.
This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo, Josephine A. Robertson, Andrea Aparicio, Kirsten Seale, Qingwen Chen, Anne Richmond, Zhaozhen Du, Mahnoor Sulaiman, Shijie C Zheng, Esteban Ballestar, Charlotte AM Cecil, Bastiaan T Heijmans, Steve Horvath, Varun B. Dwaraka, Jessica Lasky‐Su, Ryan Smith, Riccardo E. Marioni, Andrew E Teschendorff   +17 more
wiley   +1 more source

Characteristics of patients referred to Canary Island pneumology outpatient services for chronic obstructive pulmonary disease: the EPOCan study

BMC Research Notes, 2022
Objective Assessing patients with chronic obstructive pulmonary disease (COPD) accounts for 30% of all pneumology outpatient evaluations. COPD is a heterogeneous disease and generates a massive public health problem.
Juan Marco Figueira-Gonçalves, José María Hernández-Pérez, Carlos Cabrera-López, Aurelio Luis Wangüemert-Pérez, Ignacio García-Talavera, Yolanda Ramallo-Fariña, Carolina Ramos-Izquierdo, Luis Manuel González-García, Sara Guanche-Dorta   +8 more
doaj   +1 more source

Role of inflammatory cells in airway remodeling in COPD

International Journal of COPD, 2018
COPD is characterized by chronic bronchitis, chronic airway obstruction, and emphysema, leading to a progressive and irreversible decline in lung function. Inflammation is central for the development of COPD.
Yujie Wang, Jiayan Xu, Y. Meng, I. Adcock, X. Yao   +4 more
semanticscholar   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Impact of Intraoperative Fluid Volume on Complications After Minimally Invasive Esophagectomy: Analysis of 8782 Patients From the Japanese National Clinical Database

Annals of Gastroenterological Surgery, EarlyView.
This multicenter cohort study of 8782 esophagectomies in Japan found that higher intraoperative fluid volume significantly increased the risk of pneumonia after minimally invasive esophagectomy. Avoiding fluid overload may help reduce postoperative pneumonia.
Akihiko Okamura, Hideki Endo, Masayuki Watanabe, Hiroyuki Yamamoto, Hirotoshi Kikuchi, Naoki Yoshimura, Hideki Ueno, Masayuki Chida, Ken Shirabe   +8 more
wiley   +1 more source

β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle

Frontiers in Immunology, 2017
β-Catenin is a multifunctional protein that apart from its role in proliferative and differentiation events, also acts upon inflammatory processes, mainly via interaction with nuclear factor-κB (NF-κB). However, there is still controversy as to whether β-
Tim Koopmans, Tim Koopmans, Roos Eilers, Roos Eilers, Mark Menzen, Mark Menzen, Andrew Halayko, Reinoud Gosens, Reinoud Gosens   +8 more
doaj   +1 more source

Disease burden of COPD in China: a systematic review

International Journal of COPD, 2018
Chronic obstructive pulmonary disease (COPD) is one of the main contributors to the global burden of disease. The aim of this systematic review was to quantify the disease burden of COPD in China and to determine the risk factors of the disease.
Bifan Zhu, Yanfang Wang, J. Ming, Wen Chen, Luying Zhang   +4 more
semanticscholar   +1 more source

The Effectiveness of Anti‐Adhesion Barriers on Prevention of Postoperative Adhesive Bowel Obstruction: Disease‐Free Survival Analysis

Annals of Gastroenterological Surgery, EarlyView.
We performed a survival analysis of abdominal gastroenterological cancer surgery cases with and without anti‐adhesive barriers, with the development of adhesive bowel obstruction as the outcome. The incidence of adhesive bowel obstruction was significantly lower in patients undergoing open or laparoscopic colorectal surgery in the anti‐adhesive ...
Shota Ebinuma, Susumu Kunisawa, Daisuke Takada, Kiyohide Fushimi, Akinobu Taketomi, Yuichi Imanaka   +5 more
wiley   +1 more source

Airway wall splice quantitative trait locus analysis reveals novel downstream mechanisms for known asthma single-nucleotide polymorphisms

ERJ Open Research, 2023
Tessa M. Kole, Simon D. Pouwels, Rene Bults, Marlies E. Ketelaar, Victor Guryev, Lisanne Koll, Huib A.M. Kerstjens, Martijn C. Nawijn, Alen Faiz, Maarten van den Berge   +9 more
doaj   +1 more source