Results 61 to 70 of about 5,675 (258)

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Therapeutic Targeting of ATP7B in Ovarian Carcinoma. [PDF]

, 2009
PURPOSE: Resistance to platinum chemotherapy remains a significant problem in ovarian carcinoma. Here, we examined the biological mechanisms and therapeutic potential of targeting a critical platinum resistance gene, ATP7B, using both in vitro and in ...
Armaiz-Pena, Guillermo N, Coleman, Robert L, Danes, Christopher G, Halder, Jyotsna B, Jennings, Nicholas B, Lee, Jeong-Won, Leshane, Erik S, Lin, Yvonne G, Lopez-Berestein, Gabriel, Lutsenko, Svetlana, Mangala, Lingegowda S, Nick, Alpa M, Schmandt, Rosemarie, Shahzad, Mian M K, Siddik, Zahid H, Sood, Anil K, Spannuth, Whitney A, Tanaka, Takemi, Vivas-Mejia, Pablo E, Wolf, Judith K, Zuzel, Vesna   +20 more
core   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase. [PDF]

, 1987
Specialized proton-secreting cells known collectively as mitochondria-rich cells are found in a variety of transporting epithelia, including the kidney collecting duct (intercalated cells) and toad and turtle urinary bladders.
Brown, D, Gluck, S, Hartwig, J
core  

Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island" [PDF]

, 2015
The presence of metal resistance determinants in bacteria usually is attributed to geological or anthropogenic metal contamination in different environments or associated with the use of antimicrobial metals in human healthcare or in agriculture.
Asiani, Karishma, Department of Biology Skidmore College Saratoga Springs NY USA, Department of Pharmaceutical Sciences, Texas Tech University TX USA, Department of Plant and Environmental Science, University of Copenhagen, Denmark, Division of Dermatology and Venerology Depot Clinical Sciences, Lund University, Sweden, German, Nadezhda, Hao, Xiuli, Hobman, John L., Instituto de Biologia Molecular y Celular de Rosario, Argentina, Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, People's Republic of China, Lutay, Nataliya, Luthje, Freja L., McDevitt, Sylvia Franke, Qin, Yanan, Rensing, Christopher, School of Biosciences University of Nottingham, Sutton Bonington Campus, Sutton Bonington LE12 5RD UK, Soncini, Fernando C., State Key Lab of Urban and Regional Ecology, Chinese Acad Sci, Zhang, Siyu, Zhu, Yong-Guan   +19 more
core   +3 more sources

Pierceable, Water‐Resistant, and Transparent Nanofilm Electrodes Comprising Carbon Nanotubes for Long‐Term Monitoring of Plant Electrophysiology

Advanced Science, EarlyView.
Ultra‐flexible electrodes composed of single‐walled carbon nanotubes on a polymeric substrate exhibit excellent transparency, water resistance, and conformability to hairy surfaces. These non‐invasive nanofilms are easily pierced by trichomes, overcoming the structural barriers in plant electrophysiology.
Yusuke Hori, Tatsuhiro Horii, Shinji Masuda, Toshinori Fujie   +3 more
wiley   +1 more source

Structural model of the CopA copper ATPase of Enterococcus hirae based on chemical cross-linking [PDF]

, 2018
The CopA copper ATPase of Enterococcus hirae belongs to the family of heavy metal pumping CPx-type ATPases and shares 43% sequence similarity with the human Menkes and Wilson copper ATPases.
Kock, Gerd, Lübben, Mathias, Portmann, Reto, Solioz, Marc, Stoll, Raphael, Young, Malin   +5 more
core  

Mass spectrometric studies of Cu(I)-binding to the N-terminal domains of B. subtilis CopA and influence of bacillithiol [PDF]

, 2019
CopA is a Cu(I)-exporting transmembrane P1B-type ATPase from Bacillus subtilis. It contains two N-terminal cytoplasmic domains, CopAab, which bind Cu(I) with high affinity and to form higher-order complexes with multiple Cu(I) ions.
Hamilton, Chris J., Kay, Kristine L., Le Brun, Nick E.   +2 more
core   +1 more source

Relative Exchangeable Copper Confirms Wilson Disease and Supports Reclassification of the ATP7B p.Met665Ile Variant With Conflicting Pathogenicity Evidence

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Wilson disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B mutations. Diagnosis is usually straightforward in symptomatic patients, but can be challenging in children and adolescents with mild liver disease, borderline urinary copper excretion, or inconclusive genetic findings.
Emanuele Nicastro, Caterina Zuccoli, Roberto Marozzi, Antonino Barletta, Lisa Licini, Paola Tebaldi, Valeria Casotti, Mariangela Stinco, Lidia Pezzani, Maria Iascone, Lorenzo D'Antiga   +10 more
wiley   +1 more source