Results 11 to 20 of about 3,041,653 (403)

Copper induces cell death by targeting lipoylated TCA cycle proteins

Science, 2022
Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown.
Peter Tsvetkov, S. Coy, Boryana Petrova, Margaret B. Dreishpoon, A. Verma, M. Abdusamad, J. Rossen, Lena M Joesch-Cohen, Ranad Humeidi, R. Spangler, J. Eaton, Evgeni M. Frenkel, M. Kocak, S. M. Corsello, S. Lutsenko, Naama Kanarek, S. Santagata, T. Golub   +17 more
semanticscholar   +1 more source

Copper homeostasis and cuproptosis in health and disease

Signal Transduction and Targeted Therapy, 2022
As an essential micronutrient, copper is required for a wide range of physiological processes in virtually all cell types. Because the accumulation of intracellular copper can induce oxidative stress and perturbing cellular function, copper homeostasis ...
Liyun Chen, J. Min, Fudi Wang
semanticscholar   +1 more source

Large-Area Synthesis of High-Quality and Uniform Graphene Films on Copper Foils [PDF]

Science, 2009
Growing Graphene The highest quality graphene samples, single-atom-thick layers of carbon, are suspended flakes exfoliated from graphite, but these samples are very small in size (square micrometers).
Xuesong Li, Weiwei Cai, J. An, Seyoung Kim, J. Nah, Dongxing Yang, R. Piner, A. Velamakanni, I. Jung, E. Tutuc, S. Banerjee, L. Colombo, R. Ruoff   +12 more
semanticscholar   +1 more source

Copper metabolism in cell death and autophagy

Autophagy, 2023
Copper is an essential trace element in biological systems, maintaining the activity of enzymes and the function of transcription factors. However, at high concentrations, copper ions show increased toxicity by inducing regulated cell death, such as ...
Qian Xue, Rui Kang, D. Klionsky, D. Tang, Jinbao Liu, Xin Chen   +5 more
semanticscholar   +1 more source

Copper-dependent autophagic degradation of GPX4 drives ferroptosis

Autophagy, 2023
Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays a master role in blocking ferroptosis by eliminating phospholipid ...
Qian Xue, Ding Yan, Xi Chen, Xiaofen Li, Rui Kang, D. Klionsky, G. Kroemer, Xin Chen, D. Tang, Jinbao Liu   +9 more
semanticscholar   +1 more source

A druggable copper-signalling pathway that drives inflammation

Nature, 2023
Cellular uptake of copper( ii ) by CD44 has a key role in regulating cellular plasticity via copper( ii )-dependent downstream signalling events. Inflammation is a complex physiological process triggered in response to harmful stimuli^ 1 .
S. Solier, S. Müller, T. Cañeque, A. Versini, Arnaud Mansart, Fabien Sindikubwabo, Leeroy Baron, Laila Emam, P. Gestraud, G. Pantoș, Vincent Gandon, C. Gaillet, Ting-di Wu, F. Dingli, D. Loew, S. Baulande, Sylvère Durand, V. Sencio, C. Robil, F. Trottein, D. Péricat, Emmanuelle Näser, C. Cougoule, E. Meunier, Anne-Laure Bègue, Hélène Salmon, N. Manel, A. Puisieux, S. Watson, M. Dawson, N. Servant, G. Kroemer, D. Annane, Raphaël Rodriguez   +33 more
semanticscholar   +1 more source

Copper homeostasis and copper-induced cell death in the pathogenesis of cardiovascular disease and therapeutic strategies

Cell Death and Disease, 2023
Copper is a vital mineral, and an optimal amount of copper is required to support normal physiologic processes in various systems, including the cardiovascular system.
Xinyue Chen, Qi Cai, Ruikai Liang, Deju Zhang, Xiao Liu, Meiying Zhang, Yan Xiong, Minxuan Xu, Qi Liu, Pengyang Li, P. Yu, Ao Shi   +11 more
semanticscholar   +1 more source

Role of Copper on Mitochondrial Function and Metabolism

Frontiers in Molecular Biosciences, 2021
Copper is essential for life processes like energy metabolism, reactive oxygen species detoxification, iron uptake, and signaling in eukaryotic organisms.
L. Ruíz, Allan Libedinsky, Alvaro A. Elorza   +2 more
semanticscholar   +1 more source

Making online learning accessible to disabled students: an institutional case study

Research in Learning Technology, 2006
Based on the authors' reflections on experience working at the Open University, approaches to making online learning accessible to disabled students are considered. The considerations are applicable to all concerned with online learning and indeed
Martyn Copper
doaj   +1 more source

Progress and Perspectives of Electrochemical CO2 Reduction on Copper in Aqueous Electrolyte.

Chemical Reviews, 2019
To date, copper is the only heterogeneous catalyst that has shown a propensity to produce valuable hydrocarbons and alcohols, such as ethylene and ethanol, from electrochemical CO2 reduction (CO2R).
Stephanie Nitopi, Erlend Bertheussen, S. Scott, Xinyan Liu, A. Engstfeld, S. Horch, B. Seger, I. Stephens, Karen Chan, C. Hahn, J. Nørskov, T. Jaramillo, I. Chorkendorff   +12 more
semanticscholar   +1 more source