Results 41 to 50 of about 1,038,498 (299)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Biomolecular Mode of Action of Metformin in Relation to Its Copper Binding Properties [PDF]

, 2014
Metformin (Metf), the most commonly used type 2 diabetes drug, is known to affect the cellular housekeeping of copper. Recently, we discovered that the structurally closely related propanediimidamide (PDI) shows a cellular behavior different from that of
Paterson, Martin J; id_orcid, Rena, Graham; id_orcid, Erhardt, Stefan, Repiscak, Peter, Rena, Graham, Paterson, Martin J.   +5 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Theft in Price-Volatile Markets: On the Relationship between Copper Price and Copper Theft [PDF]

, 2011
Recently, against a backdrop of general reductions in acquisitive crime, increases have been observed in the frequency of metal theft offences. This is generally attributed to increases in metal prices in response to global demand exceeding supply.
Belur, J, Sidebottom, A, Shane D. Johnson, Johnson, SD, Bowers, K, Jyoti Belur, Lisa Tompson, Aiden Sidebottom, Kate Bowers, Tompson, L   +9 more
core   +1 more source

Copper oxide foam with high specific surface area for electrocatalytic reduction of CO2 to C2+ products

cMat
The carbon dioxide reduction reaction (CO2RR) for the synthesis of high‐energy‐density and high‐value multi‐carbon (C2+) products has demonstrated considerable potential for practical applications. In this work, we design a novel copper oxide foam (OD‐Cu
Yan‐Xia Feng, Jian Hao, Song Zhu, Bai‐Wen Zhang, Yan Chen   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The Copper Technology Roadmap 2030 [PDF]

, 2016
Copper has been vital to industrialised human development in electricity, plumbing and communications. Patterns of demand have changed as new materials have replaced some traditional uses of copper, however copper remains a crucial material for human ...
Worsley, Hudson, Harrington, Alex, Xinying Liu, Nana, Brinson, Ashley, Klim, Harriet, Bean, Will, Waters, Ben   +6 more
core  

A differential genome-wide transcriptome analysis : impact of cellular copper on complex biological processes like aging and development [PDF]

, 2012
The regulation of cellular copper homeostasis is crucial in biology. Impairments lead to severe dysfunctions and are known to affect aging and development.
Servos, Jörg, Hamann, Andrea, Andrea Hamann, Jörg Servos, Heinz D. Osiewacz (120841), Osiewacz, Heinz D., Andrea Hamann (120836), Carolin Grimm (120839), Grimm, Carolin, Jörg Servos (120834), Heinz D Osiewacz, Carolin Grimm, Osiewacz Heinz D., Servos Jörg, Grimm Carolin, Hamann Andrea   +15 more
core   +2 more sources

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source